Zamatto F, et al. BMJ Glob Health 2017;2:e000450. doi:10.1136/bmjgh-2017-000450 It was in the 1980s when the first bodies of migrants and refugees from the global south were washed up on European shores. In the absence of safe and legal alternatives, people continue to embark on perilous sea journeys for a myriad of reasons; they are fleeing persecution, violence and poverty and seeking freedom...

Malposture of the long fetal extremities is the major cause of dystocia in the mare (Vandeplassche 1987; Frazer et al. 1997a). Many of these cases can be resolved safely and rapidly by fetotomy if the fetus is determined to be dead. One or 2 well-placed fetotomy cuts can dramatically shorten the intervention time and permit atraumatic delivery of a nonviable fetus. However, if the obstetrician ...

Lunar meteorite EET 96008 is a fragmental breccia that predominantly consists of basaltic mineral clasts (0.5–2 mm), along with minor lithic fragments and breccia clasts. The matrix consists mainly of smaller mineral fragments ( 0.5 mm), bound by glassy cement, the majority of which are pyroxene and plagioclase. The pyroxene possesses extensive exsolution lamellae. These lamellae, up to 1 m in ...

Mutations in the RARE and MARE regulatory sequences of HNF1B are not a frequent cause of kidney/urinary tract malformation Sir, Mutations in several genes have been identified in congenital abnormalities of kidneys and urinary tract (CAKUT): heterozygous mutations in HNF1β account for 8%, while other genes (PAX2, EYA1, SALL1, SIX1) have been identified as causing isolated renal hypo/dysplasia t...

Results on procedures for freezing stallion semen and the subsequent fertility during 20 years are presented. The present system applied in French National Stud includes: (1) a freezing protocol (dilution in milk, centrifugation and addition of freezing extender (INRA82+egg yolk (2%, v/v)+glycerol (2.5%, v/v) at 22 degrees C, a moderate cooling rate to 4 degrees C and freezing at -60 degrees C/...

Using a zebrafish model of hepatoerythropoietic porphyria (HEP), we identify a previously unknown mechanism underlying heme-mediated regulation of exocrine zymogens. Zebrafish bach1b, nrf2a and mafK are all expressed in the zebrafish exocrine pancreas. Overexpression of bach1b or knockdown of nrf2a result in the downregulation of the expression of the exocrine zymogens, whereas overexpression o...