نتایج جستجو برای: mannich type reaction
تعداد نتایج: 1700335 فیلتر نتایج به سال:
The starting compound 1H-indole-2,3-dione on reaction with different substituted anilines formed the Schiff bases. The corresponding NMannich bases have been prepared by the reaction of the Schiff bases with diphenyl amine in the presence of formaldehyde. The chemical structures of the title compounds have been confirmed and elucidated by means of their physical and spectral data respectively. ...
A facile route towards highly functionalized 3(2H)-furanones via a sequential Mannich addition-palladium catalyzed ring closing has been elaborated. The reaction of 4-chloroacetoacetate esters with imines derived from aliphatic and aromatic aldehydes under palladium catalysis afforded 4-substituted furanones in good to excellent yields. 4-Hydrazino-3(2H)-furanones could also be synthesized from...
A series of mannich bases (3a-3j) were synthesized by the reaction of 4-[2-methyl-4-oxo-4H-quinazolin-3-yl] benzoic acid (2) with formaldehyde and appropriate amines by conventional technique. The procedure afforded various quinazolinone derivatives with 75% yield. Structures were characterized by means of spectral data. All the synthesized compounds were subjected to biological evaluation for ...
The title compound, C(18)H(21)NO(3), was obtained via a double Mannich condensation reaction of 6-methyl-tetra-hydro-isobenzofuran-1,7(3H,7aH)-dione with formaldehyde and benzyl-amine. The mol-ecule contains three fused rings of which the cyclo-hexa-none and piperidine rings adopt chair conformations and the furan-one ring assumes an envelope conformation. An inter-molecular C-H⋯π inter-action ...
A series of aminoacetylenicoxyphthalimide namely N-[4-(t-amino)-2-butynyloxy] phthalimides were synthesized from the reaction of N-hydroxyphthalimide with propargyl bromide in sodium ethoxide to generate N-(2-butynyloxy)phthalimide. The desired compounds were prepared through Mannich reaction of N-(2-butynyloxy)phthalimide with formaldehyde, appropriate amine in peroxide-free dioxin and cuprous...
Ph3PAuOTf is identified as a powerful catalyst for the addition of difluoroenol silyl ethers to N-Boc isatin ketimines and other two kinds of active cyclic ketimines. This represents the first Au(i)-catalyzed Mukaiyama-Mannich reaction, and the corresponding non-fluorinated enol silyl ether proves to be even much more reactive under the same conditions. This method paves the way to the total sy...
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