نتایج جستجو برای: mannich reaction

تعداد نتایج: 412927  

Journal: :Biological & pharmaceutical bulletin 2002
Halise Inci Gul Tarja Ojanen Osmo Hänninen

The development of resistance to current antifungal therapeutics drives the search for effective new agents. The fact that some acetophenone-derived Mannich bases had shown antifungal activities in our previous studies led us to design and synthesize acetophenone-derived bis Mannich bases, B1-B5, bis(beta-aroylethyl)methylamine hydrochlorides, to evaluate their antifungal activity. These bis Ma...

2000
K. WoŸniak E. Grech

Structural properties of two model solid Schiff-Mannich bases: 7-[(1-{5-bromo-3[(diethylamino)methyl]-2-hydroxyphenyl}methylidyne)amino]-4-methylcoumarin and N,N -bis{5-bromo-3-[(diethylamino)methyl]salicylidene}-1,2-diaminoethane have been investigated. In both cases a neutral intramolecular O–H...N hydrogen bonding is formed with participation of the Schiff parts of the molecules only. Single...

Journal: :Chemistry 2006
Tomoaki Hamada Kei Manabe Shū Kobayashi

Catalytic asymmetric Mannich-type reactions of an alpha-hydrazono ester with silicon enolates in aqueous media have been developed by using ZnF2 and chiral diamines as catalysts. In these reactions, both Zn2+ and a fluoride anion were necessary to achieve high yields and enantioselectivities, suggesting a double activation mechanism, in which Zn2+ activates the alpha-hydrazono ester and the flu...

Journal: :ChemistrySelect 2021

1,2,4-Triazole-3-one (3), acquired from cinnamaldehyde was converted to the corresponding carbox(thio)amides via several steps (6 a–c). Their reaction with sodium hydroxide gave 1,2,4-triazole derivatives (7 Compound 3 treatment 2-bromo-1-(4-chlorophenyl) ethanone or 2-chloro-1-(2,4-dichlorophenyl)ethanone afforded compounds 8 a,b and by reducing these reduction products were obtained (9 a,b). ...

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