In their recent study published in Oncotarget Shimabukuro-Vornhagen and colleagues present interesting data on tumor-associated B cell subsets in patients with colorectal cancer [1]. The authors noted a significantly higher frequency of CD27+IgD– B cells in the peripheral blood of such patients as compared to healthy subjects. The results were interpreted as a specific B cell immune response ag...

S So ou us s l le e s sc ce ea au u d de e l l' 'U Un ni iv ve er rs si it té é e eu ur ro op pé ée en nn ne e d de e B Br re et ta ag gn ne e Etudes des mécanismes réseaux associés à la restauration préventive dans le réseau coeur à fibre optiques ACKNOWLEDGEMENTS The way you get good ideas is by working with the talented people who are also fun to be with. Orange labs is a wonderful place to ...

We have recently validated a macromolecular prodrug strategy for improved cancer chemotherapy based on two features: (a) rapid and selective binding of thiol-reactive prodrugs to the cysteine-34 position of endogenous albumin and (b) acid-sensitive promoted or enzymatic release of the drug at the tumor site [Kratz, F., Warnecke, A., Scheuemann, K., Stockmar, C., Schwab, J., Lazar, P., Druckes, ...

Tamoxifen (TAM) resistance is an important clinical problem in the treatment of breast cancer. In order to identify the mechanism of TAM resistance for estrogen receptor (ER)-positive breast cancer, we screened the transcriptome using RNA-seq and compared the gene expression profiles between the MCF-7 mamma carcinoma cell line and the TAM-resistant cell line TAMR/MCF-7, 52 significant different...

Present condition.?The tumour spriF.gs from the level of the left mamma and hangs down as far as the left great trochanter of the femur, its base or pedicle measures five inches in width and nine inches in girth or circumference. The length of the tumour from base or pedicle to its most dependent point is twelve inches, and the circumference of the tumour at its thickest portion measures fourte...

PURPOSE Tibolone is a selective tissue estrogenic activity regulator, approved for the treatment of vasomotor symptoms in postmenopausal women. We have done an exploratory, double-blind, randomized, placebo-controlled pilot trial to investigate the tissue-specific effects of 2.5 mg tibolone on breast cancer in postmenopausal women, in particular on tissue proliferation (STEM, Study of Tibolone ...

Pretreatment of animal cells with X-ray (4, 14, 18), thymidine analogs (19), and chemical carcinogens (2, 3, 9) increases the sensitivity of survivingcells to transformation by DNA-oncogenic viruses. The property that many of these agents share is the abifity to induce strand breaks in cellular DNA. If viral transformation is dependent upon integration of viral DNA into cellular DNA, then the e...

INTRODUCTION Autologous fat transplantation to the female breast is becoming generally accepted as a standard procedure in plastic surgery. Periglandular planes and also intrapectoral planes are used, based on the idea of having a highly vascularised matrix. To assess this surgical technique a reproducible and exact tool for volume analysis is necessary. METHODS The volume of pectoral muscles...