Key words: malignant hypertension; acute renal failure; with papilledema, suggestive of malignant hyperten-angiotensin converting enzyme inhibitors; renin sion. A grade 3/6 systolic ejection murmur and coarse crackles were heard on auscultation of the chest. No bruit was audible in the abdomen. The patient was anuric. The urine tested a ++ for

A 20-year-old woman presented with malignant hypertension, pulmonary edema, anemia, and azotemia. Blood pressure was adequately controlled only after progressively more intensive drug regimens, finally including minoxidil, nadolol, and furosemide. On these drugs, the patient developed progressive left and right heart failure, anasarca, and malnutrition. The control of hypertension, heart failur...

A longitudinal study of sequential measurement of glomerular filtration rate and effective renal plasma flow was conducted over a 5-year period of antihypertensive drug treatment, in four adult patients admitted to hospital with previously untreated malignant essential hypertension. Treatment produced a substantial and sustained lowering of systemic arterial blood pressure, compared with grossl...

Hypertensin has been assayed in the blood of patients with normal blood pressure and in those with essential hypertension in both the benign and malignant phases. 250 ml. samples of arterial blood were obtained, chemically purified, and concentrated to a volume of 1 ml. These extracts were then assayed in anesthetized rats. The concentrations of hypertensin in the blood of patients with the mal...

A 66-year-old Lithuanian female patient with a history of hypertension was diagnosed with bilateral adrenal tumors during a routine sonoscopy. Scintigraphy with metaiodobenzylguanidine and computed tomography scan revealed right 130/116/93 mm and left 85/61/53 mm pheochromocytomas. The patient suffered from hypertension with blood pressure over 240/100 mm Hg and heartbeat disturbances. Blood ad...

The mortality rate from malignant hypertension has been dramatically reduced and the morbidity and mortality attributable to essential hypertension have been significantly decreased since the introduction of potent antihypertensive drugs (Mroczek et al., 1969; Gudbrandsson et al., 1970; Veterans Administration Cooperative Group, 1970). While the efficacy of antihypertensive treatment now seems ...