Lesion of posterodorsal amygdala (PDA) has been known to produce hyperphagia and obesity in animal models. However, the influence of gender on food intake (FI), body weight (BW) and immunological parameters following PDA lesion is not yet known. The present work was carried out to study the effect of gender on the regulation of FI, BW and immunological parameters following lesions of PDA in alb...

Exercise is a physiological inducer of the cardioprotective heat shock protein, Hsp70. The putative biological events involved in signaling this response exhibit sexual dimorphism. Thus, it was hypothesized that exercise-mediated induction of Hsp70 would demonstrate sex specificity. After treadmill running, male rats exhibited 2-fold greater levels of cardiac Hsp70 relative to the levels in gon...

OBJECTIVE To investigate the effect of low-selenium diet on the liver and kidneys of rats and explore the role of macrophage polarization into M1 and M2 phenotypes in liver and kidney injuries. METHODS Twenty-four rats (12 female and 12 male) were randomly divided into control group and low-selenium group and fed with normal chow (dietary selenium of 0.18 mg/kg) and low-selenium diet (dietary...

Metabolism, excretion, and pharmacokinetics of a highly selective EP2 agonist, CP-533,536 (3-{[4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid), were investigated in male and female Sprague-Dawley rats following an intravenous administration of a single 15 mg/kg dose of [(14)C]CP-533,536. At 144 h after the dose, the cumulative excretion of radioactivity averaged ...

Glyburide, an insulin secretagogue and an insulin-sensitizing agent, lowers blood pressure in normal male and female dogs when administered acutely. Because insulin resistance may contribute to spontaneous hypertension in rats, we sought to determine if long-term administration of glyburide (5 mg/kg per day by diet, age 5 weeks to 5 months) would lower blood pressure in male and female stroke-p...

The objective of this study was to evaluate the antioxidant properties Senna siamea and their effects on sports performance in rats. A total 15 male Wistar rats were used divided into 3 groups. GrpEDSE GrpED+Entr groups each subjected 7 mL/kg distilled water by body weight, then GrpSS+Entr group treated with 300 mg/kg weight aqueous extract leaves. Rats belonging GrpED+Entr, swimming for fiftee...

Verticinone, the main active component in F. hupehensis, exhibits potent antitussive and expectorant effects. Here, a LC-MS method was developed and applied to study the pharmacokinetics, tissue distribution and excretion of verticinone in rats, and its plasma protein binding in vitro. A significant gender difference in the pharmacokinetics of verticinone in rats was observed, as its absolute o...

The study was conducted to investigate how Ferula rigidula extract affected sperm profile, antioxidant parameters, and stereological profile in experimental diabetic rats. Performed on forty-nine male rats were randomly assigned control group, + group 1, 2, glibenclamide 2. While count, motility, testosterone hormone, germinal epithelial volume, height decreased the abnormal malondialdehyde lev...

Abstract Objectives The number of studies examining the circulating level change betatrophin and cartonectin in metabolic syndrome applying different loads exercise is limited. purpose present study was to investigate how exercises regulate levels induced rats. Methods A total 24 Wistar-Albino male rats were used study. Rats divided into four groups as follows; G1: control group (fed with stand...