Spermatogenesis is a complex process that involves stem-cell renewal, genome reorganization and genome repackaging, and that culminates in the production of motile gametes. Problems at all stages of spermatogenesis contribute to human infertility. Male infertility, is characterized by hypogonadism, decreased semen quality or ejaculatory dysfunction, accounts for approximately 20% of infertility...

Objectives. Intrauterine insemination (IUI) is frequently used as a first line strategy in the treatment of male and unexplained infertility. Threshold levels of sperm parameters associated with IUI success are controversial. The aim of this study was to evaluate the influence of sperm parameters on the outcome of IUI. Study Design. A prospective observational study. Patients and methods. This ...

BACKGROUND Though exogenous testosterone is known for its contraceptive effects in men, it is sometimes prescribed by medical practitioners for the treatment of male factor infertility in the mistaken belief that exogenous testosterone improves sperm count. The aim of this study was to evaluate the scope of testosterone use in the treatment of male factor infertility by medical practitioners in...

the latest micromanipulative technique, intracytoplasmic sperm injection (icsi), has been very successful in cases of severe male factor infertility. the main objective of this study is to report the results of our first experience with icsi in cases of male factor infertility, as well as patients who had failed their previous cycles with conventional in vitro fertilization (ivf). normal fertil...

OBJECTIVE To investigate the role of DNA damage induced by beta-nicotinamide adenine dinucleotide phosphate (NADPH) in human spermatozoa. DESIGN Prospective controlled study. SETTING Male infertility clinic at the Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio. PATIENT(S) Twenty-eight men undergoing infertility screening. INTERVENTION(S) Chemiluminescence as...

background: high level of semen reactive oxygen species is considered as an important factor in male infertility. sesame has antioxidant properties, which could be effective on improvement of semen parameters. this study was designed to determine the effects of sesame on sperm quality.   materials and methods: twenty‑five infertile men entered this clinical trial. they were treated with a 3â€...

PURPOSE To determine whether patients with male factor infertility can be accurately identified by calculating a novel semen quality score and measuring levels of reactive oxygen species during routine infertility screening. METHODS Semen samples from 133 patients and 91 healthy donors were evaluated with manual and computer-assisted semen analysis. A principal component analysis model was em...

Background: Facing infertility put too much emotional stress and physical burden on infertile couples that make it difficult to deal with. According to this fact that infertility in some men appears with specified disorder but in most cases there is no clear cause for male infertility which determine the special attention to lifestyle and environmental factors. In this study the effects of smok...

Assisted reproductive technologies (ART) have revolutionized the treatment of infertility. However, many types of infertility may still not be addressable by ART. With recent successes in identifying many of the genetic factors responsible for male infertility and the future prospect of whole individual human genome sequencing to identify disease causing genes, the possible use of gene therapy ...

context correct timing of diagnostic laparoscopy for unexplained infertility management remains as a debate for clinicians. a cost-effective strategy of diagnostic laparoscopy utilization for unexplained infertile patients is much needed. evidence acquisition detailed evaluation of the articles extracted from a “pubmed” and “cochrane database” search using “unexplained infertility and diagnosti...