background: the capacity of human hbaa erythrocytes of non-malarious blood to withstand osmotic stress in the presence of five antimalarial drugs, chloroquine phosphate, quinine, fansidartm, coartemtm and halfantm was studied in vitro. materials and methods: aqueous solutions of four increasing concentrations of the drugs used in this investigation were in the order: 0.2%, 0.4%, 0.6% and 0.8% (...

Sih.?Regarding Dr. Subra Row's opinion of using " quinine in pregnancy," I beg to state that in my experience "quinine" rarely does harm to a pregnant women suffering from malarial fever. Recently I treated two cases of advanced pregnancy (one seven months' pregnancy and another nine months' pregnancy), suffering from malarial fever (both with high fever, enlarged spleen and liver). I treated t...

The use of natural antioxidants as mitigating agents has become prevalent. Garlic (Allium sativum) is one such agent which has been proven to have antibacterial, antiseptic, antifungal, antiparasitic, anticoagulant and antitumor properties. The present investigation deals with the ameliorative effects of Allium sativum on the antimalarial drug induced hepato-toxicity. Artesunate is being used a...

Vector-borne diseases constitute an enormous burden on public health across the world. However, despite the importance of interactions between infectious pathogens and their respective vector for disease transmission, the biology of the pathogen in the insect is often less well understood than the forms that cause human infections. Even with the global impact of Plasmodium parasites, the causat...

Artemisinin is a powerful drug that has been combined with other antimalarial drugs to combat malaria and it crucial recent achievements in reducing cases. However, the emergence of Plasmodium falciparum resistance against artemisinin become serious problem treatment. Our previous studies reported alkalinised digestive vacuole P. similarly concanamycin A. Concanamycin A specific inhibitor V-typ...

New anti-malarial drugs are needed to address the challenge of artemisinin resistance and to achieve malaria elimination and eradication. Target-based screening of inhibitors is a major approach for drug discovery, but its application to malaria has been limited by the availability of few validated drug targets in . Here we utilize the recently available large-scale gene Plasmodium essentiality...

Malaria is a major world health problem. It results from infection of parasites belonging to the genus Plasmodium. Plasmodium falciparum and Plasmodium vivax cause the major human malarias, with P falciparum being the more virulent. During their blood stages of infection, both P falciparum and P vivax induce anemia. Severe malarial anemia caused by P falciparum is responsible for approximately ...