نتایج جستجو برای: mafbx

تعداد نتایج: 254  

Journal: :The British journal of nutrition 2009
Rafat A Siddiqui Samira Hassan Kevin A Harvey Tamkeen Rasool Tapas Das Pradip Mukerji Stephen DeMichele

Muscle wasting or cachexia is caused by accelerated muscle protein breakdown via the ubiquitin-proteasome complex. We investigated the effect of curcumin c3 complex (curcumin c3) on attenuation of muscle proteolysis using in vitro and in vivo models. Our in vitro data indicate that curcumin c3 as low as 0.50 microg/ml was very effective in significantly inhibiting (30 %; P < 0.05) tyrosine rele...

2015
Jing Zhang Shu-Lin Fu Yan Liu Yu-Lan Liu Wen-Jun Wang Y-h. Taguchi

MicroRNAs (miRNAs) constitute a class of non-coding RNAs that play a crucial regulatory role in skeletal muscle development and disease. Several acute inflammation conditions including sepsis and cancer are characterized by a loss of skeletal muscle due primarily to excessive muscle catabolism. As a well-known inducer of acute inflammation, a lipopolysaccharide (LPS) challenge can cause serious...

2016
Rashmi Supriya Bjorn T. Tam Xiao M. Pei Christopher W. Lai Lawrence W. Chan Benjamin Y. Yung Parco M. Siu

Anti-cancer agent doxorubicin (DOX) has been demonstrated to worsen insulin signaling, engender muscle atrophy, trigger pro-inflammation, and induce a shift to anaerobic glycolytic metabolism in skeletal muscle. The myotoxicity of DOX in diabetic skeletal muscle remains largely unclear. This study examined the effects of DOX on insulin signaling, muscle atrophy, pro-/anti-inflammatory microenvi...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2016
Yulan Liu Xiuying Wang Huanting Wu Shaokui Chen Huiling Zhu Jing Zhang Yongqing Hou Chien-An Andy Hu Guolong Zhang

Pro-inflammatory cytokines play a critical role in the pathophysiology of muscle atrophy. We hypothesized that glycine exerted an anti-inflammatory effect and alleviated lipopolysaccharide (LPS)-induced muscle atrophy in piglets. Pigs were assigned to four treatments including the following: 1) nonchallenged control, 2) LPS-challenged control, 3) LPS+1.0% glycine, and 4) LPS+2.0% glycine. After...

Journal: :American journal of physiology. Endocrinology and metabolism 2009
Olasunkanmi A J Adegoke Stéphanie Chevalier José A Morais Réjeanne Gougeon Scot R Kimball Leonard S Jefferson Simon S Wing Errol B Marliss

Since maximum anabolism occurs postprandially, we developed a simulated fed state with clamped hyperinsulinemia, physiological hyperglycemia, and hyperaminoacidemia (Hyper-3) and explored muscle cellular mechanisms. Whole body [1-(13)C]leucine and [3-(3)H]glucose kinetics in healthy men were compared between hyperinsulinemic, euglycemic, isoaminoacidemic (Hyper-1, n = 10) and Hyper-3 (n = 9) cl...

Journal: :Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2014
Marcus Moberg William Apró Inger Ohlsson Marjan Pontén Antonio Villanueva Björn Ekblom Eva Blomstrand

The purpose of the study was to investigate the specific effect of leucine on mTORC1 signalling and amino acid metabolism in connection with resistance exercise. Comparisons were made between ingestion of supplements with and without leucine. Eight young women performed leg press exercise on 2 occasions. In randomized order they received either an aqueous solution of essential amino acids with ...

2009
Ian A. Johnston Neil I. Bower

Muscle growth requires a population(s) of myogenic progenitor cells (MPCs) or myoblasts that remain capable of proliferation and are regulated by signaling pathways responsive to both nutritional status and environmental conditions. Myotube formation involves the recognition and adhesion of myoblasts, the breakdown of muscle membranes and the remodeling of the actin cytoskeleton. Myotube produc...

2009
Annabelle Z. Caron Geneviève Drouin Justine Desrosiers Frédéric Trensz Guillaume Grenier

Caron AZ, Drouin G, Desrosiers J, Trensz F, Grenier G. A novel hindlimb immobilization procedure for studying skeletal muscle atrophy and recovery in mouse. J Appl Physiol 106: 2049–2059, 2009. First published April 2, 2009; doi:10.1152/japplphysiol.91505.2008.—Skeletal muscle atrophy is a serious concern for patients afflicted by limb restriction due to surgery (e.g., arthrodesis), several art...

Journal: :The Journal of nutrition 2014
Marlou L Dirks Benjamin T Wall Rachel Nilwik Daniëlle H J M Weerts Lex B Verdijk Luc J C van Loon

Short successive periods of muscle disuse, due to injury or illness, can contribute significantly to the loss of muscle mass with aging (sarcopenia). It has been suggested that increasing the protein content of the diet may be an effective dietary strategy to attenuate muscle disuse atrophy. We hypothesized that protein supplementation twice daily would preserve muscle mass during a short perio...

2012
Adriana C. Lambertucci Rafael H. Lambertucci Sandro M. Hirabara Rui Curi Anselmo S. Moriscot Tatiana C. Alba-Loureiro Lucas Guimarães-Ferreira Adriana C. Levada-Pires Diogo A. A. Vasconcelos Donald F. Sellitti Tania C. Pithon-Curi

In this study, we investigated the effect of glutamine (Gln) supplementation on the signaling pathways regulating protein synthesis and protein degradation in the skeletal muscle of rats with streptozotocin (STZ)-induced diabetes. The expression levels of key regulatory proteins in the synthetic pathways (Akt, mTOR, GSK3 and 4E-BP1) and the degradation pathways (MuRF-1 and MAFbx) were determine...

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