Objective. To verify whether markers of metal homeostasis are related to a magnetoencephalographic index representative of glutamate-mediated excitability of the primary somatosensory cortex. The index is identified as the source strength of the earliest component (M20) of the somatosensory magnetic fields (SEFs) evoked by right median nerve stimulation at wrist. Method. Thirty healthy right-ha...

A model including detailed gas phase chemistry previously applied to nitrate ester and nitramine solid propellants and their major ingredients has been successfully applied to the pure energetic ingredient nitroguanidine and to M30, a triple base propellant which contains nitroguanidine. This is the first modeling of either based on a detailed gas phase mechanism. Computed burning rates are in ...

The goal of this research is to better understand the stress-strain behaviour plain and fibre reinforced M30 grade SCC mixtures. experimental stress strain relationship revealed that all changes had a minor effect on curve's first section. FRSCC mixtures has improved with addition fibres, resulting in lower values for same stresses. At peak loads, mixes, notably SFRSCC HFRSCC showed an increase...

s | 47 Experiment 2. FSL and FRL animals received single injections of CBD (10 or 30 mg/Kg, ip), ketamine (10 mg/Kg, ip) or vehicle and were submitted to the forced swimming test (FST) 1h later. Results: Experiment 1. Acute treatment with CBD (30 mg/Kg) immediately after the pretest, but not with imipramine, significantly reduced the number of escape failures during the test, an antidepressant-...

Abstract Background Tofacitinib is an oral small molecule Janus kinase inhibitor for the treatment of ulcerative colitis. The long-term, Phase 3b/4 RIVETING study (NCT03281304) assessed efficacy and safety tofacitinib dose reduction from 10 mg twice daily (BID) maintenance therapy to 5 BID in patients (pts) stable remission.1 We present a final analysis after ≥30 months treatment. Methods was d...