We present results on using cooperative interactions to shield liposomes by incorporating multiple hydrophobic anchoring sites on polyethylene glycol (PEG) polymers. The hydrophobically-modified PEGs (HMPEGs) are comb-graft polymers with strictly alternating monodisperse PEG blocks (M(w)=6, 12, or 35 kDa) bonded to C18 stearylamide hydrophobes. Cooperativity is varied by changing the degree of ...

Aqueous solutions of poly(ethylene glycol) (PEG) in a 10 mM ammonium acetate buffer are electrosprayed, and the maximum charge state on the resulting gas-phase ions is reduced to unity using a radioactive source. The mobility distribution of these charged particles is then measured in air in a differential mobility analyzer of unusually high resolution. The relation Z(m) between the mobility Z ...

In this paper, a metal-organic framework MOF-5 loaded polyethylene glycol (PEG) nanowire was used to form composite phase change material PEG/MOF-5. The molecular dynamics method simulate the thermal conductivity, melting point and latent heat by G-K function pseudo-supercritical path method, respectively. results show that pores of promote increase angle PEG main chain extension helical segmen...

In this single-center, double-blind, randomized, sham-controlled, prospective trial at the U.S. Air Force School of Aerospace Medicine, the effects of 2.4 atmospheres absolute (ATA) hyperbaric oxygen (HBO₂) on post-concussion symptoms in 50 military service members with at least one combat-related, mild traumatic brain injury were examined. Each subject received 30 sessions of either a sham com...

Abstract In this work, two catalysts based on polyethylene glycol (PEG) containing sulfonic acid group and the −COOH of citric (CA) were synthesized. Characterization −SO 3 H functionalized PEG has been carried out using FT–IR. The acidity PEG–SO PEG–CA explored to investigate their catalytic efficiency towards eco-friendly production methyl salicylate via esterification salicylic methanol as a...

This article presents a thermal sintering method to fabricate porous bone tissue engineering scaffolds based on polycaprolactone (PCL), polylactic acid (PLA), and their composites. The mechanical properties, structure, biodegradability, biocompatibility of sintered were evaluated. showed porosity in the range 86–91% with pore size 75 m $$\mu$$ 400 . PCL/PLA composite Young’s modulus around 49 M...

PEG-PLGA nanoparticles (NPs) modified with anti-CD133 and tumor-targeting single-chain antibody fragment (scFV-NPs) for systemic delivery of methioninase (METase) and pemetrexed for gastric carcinoma were successfully formulated. The structure characterization and biological functions of METase-pemetrexed-loaded scFV-PEG-PLGA NPs (scFV-METase/pemetrexed-NPs) in vitro were investigated. Function...

Cancer is the leading cause of death worldwide, and metastasis is the main attribute to cancer death. CXCR4 and its natural ligand CXCL12 have been known to play a critical role in tumorigenesis, angiogenesis and metastasis. Therefore, designing a new CXCR4 antagonist to prevent tumor metastasis will be of great significance. Herein, a novel chemically synthesized peptide (E5) that has an abili...