Aim To assess ovarian reserve (OVR) by means of follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH), and antral follicle count (AFC) measurement in eumenorrheic women with breast cancer, exposed to gonadotoxic chemotherapy. Method Fifty-two women (35.3 ± 3.8 years old) with breast cancer and undergoing cyclophosphamide-containing chemotherapy were enrolled. The assessment was perfo...

February 2011, Vol. 101, No. 2 SAMJ A 30-year-old woman was seen at 24 weeks for a discrepancy between the symphysis-fundal height and the gestation by dates. Ultrasound examination revealed a twin pregnancy and showed the placentas to be implanted ‘back-to-back’ over what appeared to be a septum that extended from the uterine fundus to the cervix (Fig. 1). A bicornuate unicollis uterus was con...

The Müllerian inhibiting substance type II receptor (MISIIR) is involved in Müllerian duct regression as part of the development of the male reproductive system. In adult females, MISIIR is present on ovarian surface epithelium and is frequently expressed on human epithelial ovarian cancer cells. Müllerian inhibiting substance has been found to be capable of inhibiting the growth of primary hum...

Objective: Vaginal reconstruction in Müllerian agenesis through nonsurgical method, using serial vaginal dilators which were worn by the patients with the help of a T-shaped peri neal bandage. Materials and methods: Seven patients with Müllerian agenesis had attended the outpatient clinic between 2008 and 2013. The age of women ranged from 18 to 30 years. This clinical report describes the use ...

Objective Persistent Müllerian duct syndrome (PMDS) is a rare congenital disease characterized by the presence of rudimentary Müllerian structures within an intra-abdominal or hernial sac in a virilized male, often presenting as undescended testes. In this study, we aim to present a series of the PMDS patients who were managed by orchiopexy without removal of Müllerian remnants (MR). Material...

Anti-Müllerian hormone (AMH), secreted by immature Sertoli cells, provokes the regression of male fetal Müllerian ducts. FSH stimulates AMH production; during puberty, AMH is downregulated by intratesticular testosterone and meiotic germ cells. In boys, AMH determination is useful in the clinical setting. Serum AMH, which is low in infants with congenital central hypogonadism, increases with FS...

Hereditary, persistent, right oviduct manifested in an inbred line (PNP/DO line) from the Fayoumi breed of chickens was investigated for form of expression and mode of inheritance. Females in the PNP/DO line have varying lengths of elongated right oviducts, besides the normal left ovary, and oviducts that generally possess, irrespective of their total length, regions similar to those normally o...

Objective We compared the expression levels of Müllerian inhibiting substance (MIS)/anti-Müllerian hormone type II receptor (AMHRII) in uterine myoma and adenomyosis to evaluate the possibility of using MIS/anti-Müllerian hormone (AMH) as a biological regulator or therapeutic agent in patients with uterine leiomyoma and adenomyosis. Methods We studied normal uterine myometrium, leiomyoma, end...

Female fetuses of C57BL/Tw mice were injected subcutaneously with 50 microgram 17 beta-estradiol on day 17 of fetal life. The treatment was proved to induce ovary-independent proliferation and cornification in the vaginal epithelium in later postnatal life. These fetuses were sacrificed on day 19 or 20, or on the 3rd day after birth. Histological observation on day 19 or 20 of fetal life did no...

We have previously reported that anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting substance, the testicular glycoprotein involved in regression of the Müllerian ducts of the male fetus, induces the formation of seminiferous cord-like structures in fetal ovaries exposed to it in organ culture. We have now investigated the effect of bovine AMH, purified to homogeneity, on ovarian ...