INTRODUCTION Systemic Epstein-Barr virus-positive T-cell lymphoproliferative childhood disease is an extremely rare disorder and classically arises following primary acute or chronic active Epstein-Barr virus infection. It is characterized by clonal proliferation of Epstein-Barr virus-infected T-cells with an activated cytotoxic phenotype. This disease has a rapid clinical course and is more fr...

Chronic rhinosinusitis (CRS) is one of the most common persistent disorders developed world, requiring input from various specialists including primary care physicians, otolaryngologists, respiratory and allergologists. B-cell lymphoproliferative (BLPDs) are a heterogenous group malignant conditions defined by an accumulation mature B lymphocytes in bone marrow, blood, lymphoid tissues. We pres...

Abstract Post-transplant lymphoproliferative disorders (PTLDs) are a common form of de novo neoplasia developing in patients with immunosuppression following transplant. The majority associated Epstein–Barr virus (EBV) infection. Cutaneous PTLD manifestations rare and not well documented literature. We present case systemic secondary extensive cutaneous involvement 4 months after allogenic stem...

A study of consecutive bone marrow aspirates from 365 patients without lymphoproliferative disorder, ten patients with chronic lymphocytic leukemia (CLL), and 25 patients with malignant lymphoma disclosed a clear separation of normal from abnormal lymphoid nodules (LN). Normal LN were found in 47% of patients and were classified into lymphoici follicles and Iymphoid infiltrates. A new entity, n...

BACKGROUND After acute infection of Epstein-Barr virus, Epstein-Barr virus-infected B cells survive but usually do not show clonal proliferation. However, Epstein-Barr virus-infected B cells occasionally acquire a proliferative capacity that provokes clonal lymphoproliferative disorders. We herein present a case with Epstein-Barr virus-infected CD30+ B cell and immunoglobulin G4+ plasmacytoid c...

Tumor necrosis factor (TNF) and Fas ligand (FasL) play major roles in the homeostasis of the peripheral immune system. This becomes dramatically obvious in the absence of a functional FasL. Mice with such a deficiency develop a profound lymphadenopathy, splenomegaly, hypergammaglobulinemia, and strain-dependent systemic autoimmune disease, and succumb to premature death. It is consequently term...