BACKGROUND Progressive massive fibrosis (PMF) is the severe form of coal workers' pneumoconiosis (CWP). Clinical observations have suggested that the components of PMF are inhomogenous. There may be a significant diversity in the magnitude of pulmonary impairment for miners with PMF. This study is intended to investigate the relationship between radiological categories of PMF and pulmonary impa...

BACKGROUND Although impaired lung function in general has been associated with an increased risk of lung cancer, past studies typically have not attempted to investigate separately the obstructive and restrictive components of respiratory impairment. To deal with this question further, data from a large (n = 176 997) cohort of male Swedish construction workers, for whom spirometry measurements ...

STUDY OBJECTIVES Health-related quality of life associated with interstitial lung disease has received little attention in clinical studies because there have been no validated methods for directly measuring it. We have assessed the validity of several generic and respiratory-specific quality-of-life instruments in patients with interstitial lung disease. DESIGN Cross-sectional study. SETTI...

Background: Various studies have documented age-related changes in cognitive abilities and neural basis. Objectives: To investigate the role of neuropsychological function tests in predicting amnestic mild cognitive impairment in the elderly. Materials & Methods: In this cross-sectional study with a correlational design, the study population included elderly people over 60 years old residing ...

BACKGROUND Emphysema, especially in the upper lobes, is frequently observed in association with idiopathic pulmonary fibrosis (IPF). However, the combination of emphysema plus IPF has received little attention. OBJECTIVE To investigate the additional functional impairment from emphysema in IPF patients. METHODS Twenty-one patients (mean age 66 y, 20 men) (Group I) who had both IPF (mean 35%...

Silicosis is the most common occupational lung disease worldwide. It leads to respiratory impairment and may have associated infections that decrease pulmonary function. We describe the case of a 55-year-old man with chronic silicosis who presented with hemoptysis and a cavitated conglomerate mass. The final diagnosis was silicotuberculosis.

Introduction Emphysema is characterized by irreversible enlargement of the airspaces distal to the terminal bronchiole, accompanied by destruction of their walls, and impairment of cardiac function. Acute exacerbation of emphysema leads to increased morbidity, mortality and, in some cases, requirement of invasive mechanical ventilation (MV). So far, no study has compared the impact of pressure-...

We previously found that, following surgical resection of approximately 58% of lung units by right pneumonectomy (PNX) in adult canines, oxygen-diffusing capacity (Dl(O(2))) fell sufficiently to become a major factor limiting exercise capacity, although the decline was mitigated by recruitment, remodeling, and growth of the remaining lung units. To determine whether an upper limit of compensati...