Background: The transformation of epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma (LUAD) into small cell cancer (SCLC) accounts for 3–14% the resistance mechanism to EGFR tyrosine kinase inhibitors (TKIs). At present, there is no relevant research explore dynamic expression EGFR-mutant proteins and genomic evolution in transformed SCLC/neuroendocrine carcinoma (NEC).

Silicosis is an important form of pneumoconiosis, which is caused by significant exposure to crystalline silica. The carcinogenicity of silica, despite traditional beliefs, in relation to lung cancer has been controversial. Lymphoepithelioma-like carcinoma of the lung, an Epstein-Barr virus-associated undifferentiated carcinoma, is a rare entity of pulmonary malignancy, which tends to affect yo...

A 62-year-old woman, who had undergone left nephrectomy for renal cell carcinoma and had received interferon-alpha for metastasis to the lung, was hospitalized because of cough, dyspnea and anorexia 16 months after nephrectomy. Chest radiography showed collapse of the right lung. We performed bronchoscopy and found a red polypoid tumor completely obstructing the right bronchus. Biopsy specimens...

Renal cell carcinoma can metastasize to virtually any organ, yet synchronous metastasis to the bladder is extremely rare. A 77-year-old woman presented with gross hematuria. Abdominal and chest computed tomography showed a bilateral renal masses, bladder dome mass, and multiple lung metastasis. Transurethral resection of the bladder tumor and sonography guided renal biopsy were performed. Both ...

I Although primary carcinoma of the lung is fairly common, representing about 10 per cent of all carcinoma cases seen a t autopsy,l the co-existence of a benign pulmonary hamartoma must be rare. Fortunately, in the case to be presented, the two lesions were in the same lung so tha t pneumonectomy removed both tumors. Had the benign lesion been in the contra-lateral lung, it would have been cons...

The multicentric origin of certain neoplasms such as those of the stomach, intestines, skin, female genitalia, and pharynx have been well documented.1’2 Until recently, this phenomenon has not been emphasized for carcinoma of the lung except in those examples designated as alveolar cell carcinoma. Excluding the latter, there have been 26 documented cases of multiple primary invasive carcinoma o...

Double primary malignancies are rarely observed in breast malignancy, and frequently documented hematological gynecological due to genetic mutations. In present case report, 48-year female presented with left carcinoma undergone surgical treatment received first chemotherapy cycle. Her general health deteriorated our center worsened dyspnea. radiological workup shown possible metastatic lung pr...

To investigate carcinogenic or cocarcinogenic properties, copper ore (Kinkaseki) and flue dust collected from a metal refinery and arsenic trioxide (As2O3) were administered into the lung of male Wistar-King rats by an intratracheal instillation method. No squamous cell carcinoma of the lung was found among the rats given three arsenical substances, while adenoma or adenocarcinoma was observed....

Malignant rhabdoid tumor was first discovered in the kidney, and rhabdoid tumor of the lung was first reported in 1995. These were included as the variants of large-cell carcinoma, according to the 1999 World Health Organization classification of lung tumors. The rhabdoid tumor of the lung exhibits aggressive biological behavior and has a poor prognosis, and only a few reports of this tumor exi...

BACKGROUND Although patients with EGFR mutated lung adenocarcinoma benefit greatly from tyrosine kinase inhibitors (TKIs), they inevitably develop acquired resistance after an average of 10-14 months of continuous treatment. METHODS We retrospectively analyzed the clinical and histopathological data of eight patients with primary lung adenocarcinoma harboring EGFR mutations that transformed i...