Methods Development of arylsulfonilamides as NNRTIs involved both the computational and synthetic methods. On the basis of extensive docking experiments, ten promising compounds out of 55 initially taken were synthesized using green protocols and their in vitro anti-HIV activity assessed in TZM bl cells by luciferase assay and reverse transcriptase (RT) inhibition assay against wild type HIV-1 RT.

MicroRNAs are involved in regulation of the central nervous system (CNS) development, and miR-181d highly expressed mature neurons. CREB is many signal pathways converged point hippocampal neurons, it plays a crucial role learning memory. In this study, we detected negative relationship between CREB1 protein expression lewis rat hippocampus development. And bioinformatic analysis showed that, m...

Introduction Ovarian cancer (OC) frequently occurs in postmenopausal women and it has higher mortality rate. Accumulating researches proved that long non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) involved the progression of chemoresistance human OC. Here, study aimed to investigate partial molecular mechanism OC chemoresistance. Material methods The levels NEAT1 microRNA-320b...

Hepatitis C virus (HCV) is a positive-sense, single-stranded RNA that causes chronic hepatitis and hepatocellular carcinoma. Cellular microRNAs (miRNAs) directly modulate the viral infectivity indirectly through targeting virus-related host factors. They play an essential role in progression of different stages HCV infection. The roles miR-196 family infection carcinoma remain poorly understood...

Abstract Background Endometrial cancer is an invasive gynecological prevalent in the world. The pathogenesis of endometrial related to multiple levels regulation, referring oestrogen, tumor-suppressor gene (e.g. PTEN ) or microRNAs miR-23a and miR-29b). Metapristone a hormone-related drug, which widely used clinical treatment cancer. However, underlying regulatory mechanism metapristone on stil...

Colon cancer constitutes a major challenge all over the world, which has fourth highest incidence and third mortality rate of cancers. Although therapeutic modalities have been improved in recent years, 5 y survival remains low. Oxymatrine is one main active compounds extracted from roots Sophora flavescens was found with effect for colon Recently, microRNAs recognized as type diagnostic progno...