BACKGROUND Peptide receptor radionuclide therapy (PRRT), employed for treatment of neuroendocrine tumors (NETs) is based on over-expression of Somatostatin Receptors (SSTRs) on NETs. It is, however, limited by high uptake and retention of radiolabeled peptide in kidneys resulting in unnecessary radiation exposure thus causing nephrotoxicity. Employing a nanocarrier to deliver PRRT drugs specifi...

We present the case of a 60-year-old man with metastatic neuroendocrine tumor of the ileum following ileal resection, being evaluated for 177Lu-based peptide receptor radionuclide therapy. 68Ga-DOTANOC PET/CT showed focal increased tracer uptake in the scrotal region without any morphologic changes on the corresponding CT images. Similar increased tracer uptake was seen on...

Aims. We study the 0.57 keV (O VII triplet) and 0.65 keV (O VIII) diffuse emission generated by charge transfer collisions between solar wind (SW) oxygen ions and interstellar H and He neutral atoms in the inner Heliosphere. These lines which dominate the 0.3-1.0 keV energy interval are also produced by hot gas in the galactic halo (GH) and possibly the Local Interstellar Bubble (LB). Methods. ...

Most breast cancer-related deaths from triple-negative breast cancer (TNBC) occur following metastasis of cancer cells and development of tumors at secondary sites. Because TNBCs lack the three receptors targeted by current chemotherapeutic regimens, they are typically treated with extremely aggressive and highly toxic non-targeted treatment strategies. Women with TNBC frequently develop metast...

Happiness as a state of mind may be universal, but its meaning is complex and ambiguous. The authors directly examined the relationships between cultural values and experiences of happiness in 2 samples, by using a measurement of values derived from Chinese culture and a measurement of subjective well-being balanced for sources of happiness salient in both the East and the West. The participant...

We study the impact of non-uniform memory accesses (NUMA) on the solution of dense general linear systems using an LU factorization algorithm. In particular we illustrate how an appropriate placement of the threads and memory on a NUMA architecture can improve the performance of the panel factorization and consequently accelerate the global LU factorization. We apply these placement strategies ...

PURPOSE To examine the effect of combining angiostatin with photodynamic therapy (PDT) using Lutetium Texaphyrin (Lu-Tex; Alcon, Fort Worth, TX) as a photosensitizer in bovine retinal capillary endothelial (BRCE) and retinal pigment epithelial (RPE) cells and to determine the mode of PDT-induced cell death in these cell lines. METHODS Cultured BRCE and RPE cells were incubated with angiostati...

A family of n-dimensional Lee spheres L is a tiling of Rn , if ∪L = Rn and for every Lu , Lv ∈ L, the intersection Lu ∩ Lv is contained in the boundary of Lu . If neighboring Lee spheres meet along entire (n−1)-dimensional faces, then L is called a face-to-face tiling. We prove the nonexistence of a face-to-face tiling of R4 with Lee spheres of different radii. c © 2005 Elsevier Ltd. All rights...

Abstract-A new parallel algorithm for the LU factorization of a given dense matrix A is described. The case of banded matrices is also considered. This algorithm can be combined with Sameh and Brent’s [SIAM J. Numer. Anal. 14, 1101-I 113. (1977)] to obtain the solution of a linear system of algebraic equations. The arithmetic complexity for the dense case is in’ ($bn in the banded case), using ...

Many of the currently popular ‘block algorithms’ are scalar algorithms in which the operations have been grouped and reordered into matrix operations. One genuine block algorithm in practical use is block LU factorization, and this has recently been shown by Demmel and Higham to be unstable in general. It is shown here that block LU factorization is stable if A is block diagonally dominant by c...