Periodontitis (PD) is known to be one of most prevalent worldwide chronic inflammatory diseases. There are several treatments including antibiotics for PD; however, since drug resistance is an increasing problem, new drugs particularly derived from plants with fewer side effects are required. The effects of trans-anethole on IL-1 β and TNF-α level in a rat model of PD were investigated and comp...

Periodontitis (PD) is known to be one of most prevalent worldwide chronic inflammatory diseases. There are several treatments including antibiotics for PD; however, since drug resistance is an increasing problem, new drugs particularly derived from plants with fewer side effects are required. The effects of trans-anethole on IL-1 β and TNF-α level in a rat model of PD were investigated and comp...

The present study investigated the effects of E. coli lipopolysaccharide (LPS) induced mastitis model in rat on the activity of antioxidant enzyme systems. To achieve this purpose, E. coli LPS were infused into the mammary gland of 12 rats 72 hr postpartum and compared with 12 rats in control group infused intramammary placebo sterile pyrogene – free, physiological saline. The...

Cells of innate immunity, mainly monocytes/macrophages, form a long-term nonspecific immunological memory during the initial encounter with pathogen, so-called trained immunity. Mevalonate pathway metabolites play an important role in formation The aim this investigation was to study effect modulators mevalonate pathway, and zoledronate, on immunity human animal monocytes/ macrophages. Material...

Hydrogen mass repartitioning (HMR) that permits time steps of all-atom molecular dynamics simulation up to 4 fs by increasing the hydrogen atoms has been used in protein and phospholipid bilayers simulations improve conformational sampling. Molecular input generation via CHARMM-GUI now supports HMR for diverse programs. In addition, considering ambiguous pH at bacterial outer membrane surface, ...

Tamarix aphylla is a commonly grown plant in Saudi Arabia and its therapeutic potential widely recognized. Here, this study, the aim was to explore role of T. leaf extract (TAE) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) mice LPS-stimulated RAW 264.7 cells. The antioxidant anti-inflammatory parameters TAE were performed through vitro assays by measuring H2O2 free radical scaven...

Abstract Objective A preliminary study was conducted to assess the role of Tinospora sinensis extract on liver in mice normal and lipopolysaccharide (LPS)-induced health-compromised conditions. Method Mice (n = 3–5) were randomly assigned into groups I IV for hepatotoxic studies. Group normal, group II given LPS (6 mg/kg, intraperitoneal [ip]), III T. only (1 g/kg/day 21 days), whereas administ...

Introduction Hypertension is a major risk factor for cardiovascular disease (CVD) and associated with increased bone loss due to excessive activity of the local renin-angiotensin system (RAS). Angiotensinogen/Angiotensin (ANG) II/Angiotensin II type 1 receptor (AT1R) axis considered as core regulating RAS activity. Azilsartan an FDA-approved selective AT1R antagonist that used treat hypertensio...

An established lipopolysaccharide (LPS) model previously described in Warmbloods, was inconsistent Standardbred horses, where lameness not detected despite the presence of synovitis. The present study aimed to determine dose LPS from E. coli O55:B5 required induce mild moderate following middle carpal joint injection horses and quantitate induced over time, with without anti-inflammatory pre-tr...

objective: stevioside is a natural non-caloric sweetener which has been reported to have anti-inflammatory activity.  the aim of  the present study was to examine in vitro and in vivo effects of  stevioside on rats  plasma levels of tumor necrosis factor- α (tnf-α),  interleukin-1β (il-1β), tnf-α and il-1β release from lipopolysaccharide(lps)-stimulated rat peripheral blood mononuclear cells (p...