نتایج جستجو برای: lox activity

تعداد نتایج: 1136550  

2015
Yufan Tang Chong Zhang Songxiao Cao Xiao Wang Hongyan Qi Hiroshi Ezura

Lipoxygenases (LOXs) play important role in the synthesis of volatile organic compounds (VOCs), which influence the aroma of fruit. In this study, we elucidate that there is a positive relationship between LOXs activity and VOC production in melon (Cucumis melo), and CmLOX genes are involved in fruit aroma generation in melon. To this end, we tested four aroma types of melon that feature a thin...

Journal: :Fudma Journal of Sciences 2023

Lipoxygenase (LOX) is an enzyme that catalyses the step-wise oxygenation of polyunsaturated fatty acids (PUFAs) to form acid hydroperoxides within living tissues. In present study, lipoxygenase was isolated from defatted and whole (full fat) conophor nut (Tetracarpidium conophorum) purified homogeneity using 60% ammonium sulphate precipitation, DEAE-sephadex A50 sephadex G-200 chromatography. T...

Journal: :Circulation research 2007
Henning Morawietz

An increased plasma level of low-density lipoprotein (LDL) is a well-known risk factor for endothelial dysfunction and atherosclerosis.1 The proatherosclerotic potential of LDL may even increase after oxidative modification to oxidized LDL (oxLDL),2 whose uptake by macrophage scavenger receptors is thought to be a key process in the formation of foam cells, the hallmark of atherosclerotic lesio...

Journal: :Circulation 2003
Dayuan Li Ling Liu Hongjiang Chen Tatsuya Sawamura Subramanian Ranganathan Jawahar L Mehta

BACKGROUND Oxidized LDL (ox-LDL) accumulation in the atherosclerotic region may enhance plaque instability. Both accumulation of ox-LDL and expression of its lectin-like receptor, LOX-1, have been shown in atherosclerotic regions. This study was designed to examine the role of LOX-1 in the modulation of metalloproteinases (MMP-1 and MMP-3) in human coronary artery endothelial cells (HCAECs). ...

2012
SIVALOKANATHAN SARVESWARAN SUBHASH C. GAUTAM JAGADANANDA GHOSH

Emerging studies indicate that metabolism of arachidonic acid through the 5-lipoxygenase (5-Lox) pathway plays a critical role in the survival of prostate cancer cells raising the possibility that 5-Lox can be targeted for an effective therapy of prostate cancer. Wedelolactone (WDL), a medicinal plant-derived natural compound, is known to inhibit ...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2006
Jiawei Chen Yong Liu Hongmei Liu Paul L Hermonat Jawahar L Mehta

OBJECTIVE LOX-1, a receptor for oxidized low-density lipoprotein, plays a critical role in atherosclerosis. Its expression is upregulated by pro-atherogenic stimuli, such as angiotensin II (Ang II). In this study, we explored LOX-1 transcriptional promoter activation in response to Ang II in human coronary artery endothelial cells (HCAECs). METHODS AND RESULTS We constructed full-length and d...

Journal: :The Biochemical journal 1999
T Aoyama T Sawamura Y Furutani R Matsuoka M C Yoshida H Fujiwara T Masaki

We have reported the cDNA cloning of a modified low-density-lipoprotein (LDL) receptor, designated lectin-like oxidized LDL receptor-1 (LOX-1), which is postulated to be involved in endothelial dysfunction and the pathogenesis of atherosclerosis. Here, we determined the organization of the human LOX-1 gene, including the 5'-regulatory region. The 5'-regulatory region contained several potential...

Journal: :Cancer research 1984
O Fodstad C T Hansen G B Cannon C N Statham G R Lichtenstein M R Boyd

To elucidate the in vivo role of natural killer (NK) cells, the growth of several murine and human tumors was studied in four variants of athymic, nude mice with different levels of NK activity. Beige-nude mice, homozygous for both the beige and the nude genes, had very low levels of NK activity, and their response to the B-cell mitogen, bacterial lipopolysaccharide, was lower than that of high...

In the recent years, the role of LOX enzymes in the cause of neoplastic diseases such as colorectal, skin, pancreatic and renal cancers has been confirmed. A new series of 1,3,4-thiadiazole derivatives bearing 2-pyridyl moiety was synthesized and their cytotoxicity was assessed using MTT protocol. Enzyme inhibitory activity of prepared compounds was also tested against 15-lipoxygenase-1 as nove...

Journal: :Molecules 2017
Renáta Kollárová Ivana Holková Drahomíra Rauová Barbora Bálintová Peter Mikuš Marek Obložinský

BACKGROUND Plant lipoxygenases (LOXs, EC 1.13.11.12) are involved in lipid degradation, regulation of growth and development, senescence, and defence reactions. LOX represents the starting enzyme of the octadecanoid pathway. The aim of the work was to purify LOX from California poppy (Eschscholtzia californica Cham.), to determine its biochemical properties and to identify and quantify the prod...

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