BACKGROUND AND PURPOSE Responses to repetitive nerve stimulation (RNS) in patients with muscle-specific tyrosine kinase (MuSK) antibody (Ab)-positive myasthenia gravis (MG) vary depending on the muscles tested. We analyzed the RNS responses of limb and facial muscles in MuSK-Ab-positive and acetylcholine receptor (AChR)-Ab-negative MG (MuSK MG) and MuSK-Ab-negative and AChR-Ab-negative [double-...

OBJECTIVES To investigate the association between measures of strength of the lower limb and trunk muscles and gait speed and to identify the muscle group that would best predict gait speed in individuals with sub-acute stroke. METHODS Using a cross-sectional observational study design, forty-four individuals with sub-acute stroke (62 years, SD=14; 4 months, SD=1 post-stroke) were assessed. T...

Key points Gait-related arm swing in humans supports efficient lower limb muscle activation, indicating a neural coupling between the upper and limbs during gait. Intermuscular coherence analyses of gait-related electromyography from 20 healthy participants identified significant alpha beta/gamma bands that share common subcortical cortical drivers coordinate rhythmic four-limb gait pattern. Ad...

The pathophysiology of amyotrophic lateral sclerosis (ALS) is very complex and still rather elusive but in recent years evidence of early involvement of the neuromuscular junctions (NMJs) has accumulated. We have recently reported that the human extraocular muscles (EOMs) are far less affected than limb muscles at the end-stage of ALS from the same donor. The present study aimed to compare the ...

[Purpose] The purpose of this study was to determine the effects of abdominal hollowing during lower-limb proprioceptive neuromuscular facilitation (PNF) training on the activation of contralateral muscles. [Subjects] Twenty male college students without symptoms or signs of muscular or nervous disease participated in this experiment after signing a consent form. [Methods] All the subjects were...

Background: The purpose of this study was to investigate the effect of core stability exercises in the trunk area on lower limb alignment and lower and upper limb function in Kyokushin athletes. Methods: The statistical sample of the research consisted of 30 female kyokushin players aged 14-18 years, who were randomly divided into two control and experimental groups. The control group perform...

We describe two cases of myofibrillar myopathies, due to different gene mutations. The first was a girl with cardiomyopathy and sensory axonal neuropathy that underwent cardiac transplantation at 15 years suffers from rotatory scoliosis BAG3 mutation. second is male patient, evident limb-girdle weakness since age 3. Two muscle biopsies were performed ages 3 15, MRI, LDB3 sequence analysis also ...

To elucidate clinical trial efficacy, safety, and dosing practices of AbobotulinumtoxinA (ABO) treatment in adult patients with lower limb spasticity.A systematic literature review was performed to identify randomized controlled trials of ABO in the treatment of adult lower limb spasticity.Of the 295 records identified, 6 primary publications evaluated ABO for the management of lower limb spast...

In this article, we are interested in the modelling of the lower limb anatomical structures such as bones, muscles and tendons. The proposed method starts with an MRI acquisition during which the lower limb of a subject is scanned. 3D models are generated after a manual segmentation of the anatomical structures. However, the surface of the generated models appears not to be smooth. Furthermore,...