نتایج جستجو برای: low malignant potential

تعداد نتایج: 2297275  

2015
Rae-Kwon Kim Min-Jung Kim Ki Moon Seong Neha Kaushik Yongjoon Suh Ki-Chun Yoo Yan-Hong Cui Young Woo Jin Seon Young Nam Su-Jae Lee

Recently low dose irradiation has gained attention in the field of radiotherapy. For lack of understanding of the molecular consequences of low dose irradiation, there is much doubt concerning its risks on human beings. In this article, we report that low dose irradiation is capable of blocking the oncogenic KRAS-induced malignant transformation. To address this hypothesis, we showed that low d...

Journal: :medical journal of islamic republic of iran 0
z amirghofran from the department of immunology, shiraz university of medical sciences, shiraz, i.r. iran. mh karimi

the cytotoxic activity of ethanolic extracts of thymus vulgaris, thuja orientalis and achillea millefolium was investigated on various growing tumor cell lines. mtt colorimetric assay was used for measuring the inhibition of cell proliferation. all of the three extracts showed a relatively dose-dependent inhibition of proliferation of human breast cancer (sk-br-3, mda-mb-435) and leukemia (u937...

Journal: :iranian journal of public health 0
jie zhang 1. key laboratory of biomedical engineering & technology of shandong high school, shandong wanjie medical college , zibo, china. ruijie sun 2. dept. of medicine, shandong wanjie medical college , zibo, china. yue liu 1. key laboratory of biomedical engineering & technology of shandong high school, shandong wanjie medical college , zibo, china. guinian wang 3. dept. of laboratory medicine, the first hospital of zibo city , zibo, china. qinglu wang 1. key laboratory of biomedical engineering & technology of shandong high school, shandong wanjie medical college , zibo, china.

metallothionein (mt) manifests varying expression levels in carcinomas, and they may be considered as valuable cell cancerization biomarkers for diagnosis of patients with cancers. a meta-analysis was conducted to evaluate comprehensively the mt expression difference in various benign tumors and malignant tumors, which compared the high with low mt expression levels in patients of the available...

Journal: :iranian journal of public health 0
m. sarram m. fazel m. sadeghi

the result of the 6 years study of patients with hydatiform mole (hm) and its malignant degeneration in isfahan are presented. the over all frequency is estimated to be one hm in 440 child births. this frequency has remained relatively unchanged through out the study. increased consumption of meet did not seem to lower the frequency of hydatiform mole in our study. the over all frequency of mal...

Journal: :iranian biomedical journal 0
مصطفی سعادت mostafa saadat

it is now well established that the type la of serine/threonine protein phosphatases (pp1α) may be implicated in malignant phenotype. although the pp1α mrna level increased in livers at preneo-plastic stages of hepatocarinogenesis and all of examined rat ascites hepatomas, unexpectedly, dra-matically decreased in some of primary hepatomas. in order to elucidate the low level of pp1α mrna in som...

Kafil Akhtar, Rana Sherwani Shamshad Ahmad

Chordomas are low-grade malignant tumors of bone that occur almost exclusively in the axial  skeleton. Chordomas are rare in children and adolescents and comprise <5% of all cases and the  site of development is at the skull base. These tumors are believed to behave more aggressively  than chordomas in adults and may have unusual morphology. We herein present a rare case of chordoma in a 20-yea...

Journal: :European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 1999
R Rajentheran N R McLean C G Kelly M F Reed A Nolan

AIMS To investigate the malignant potential of oral lichen planus (OLP), a common mucocutaneous disease of unknown aetiology. The malignant potential of OLP is still controversial, with studies reporting malignant transformation rates of between 0 and 5.6%. We also aimed to identify factors that might be associated with malignant transformation. METHODS We retrospectively reviewed the records...

Nader Navabi, Zahra Atai, Zahra Khodadadi-Bohlouli

BACKGROUND AND AIM: Oral lichen planus (OLP) is a chronic, autoimmune, inflammatory disease. The progression of OLP to oral squamous cell carcinoma (OSCC) has generated a longstanding controversy about the details of this malignant transformation potential. This study aimed to do a systematic review on the molecular markers related to the malignant transformation of OLP.METHODS: We searched the...

2012
Brent A. Orr Michael C. Haffner William G. Nelson Srinivasan Yegnasubramanian Charles G. Eberhart

Epigenetic modification of DNA by cytosine methylation to produce 5-methylcytosine (5mC) has become well-recognized as an important epigenetic process in human health and disease. Recently, further modification of 5mC by the ten eleven translocated (TET) family of enzymes to produce 5-hydroxymethylcytosine (5hmC) has been described. In the present study, we used immunohistochemistry to evaluate...

Alireza Khooei Mohammad Gharedaghi Reza Ataei,

  Background and Objectives: Giant cell Tumor of bone (GCT) is often regarded as a benign tumor, but its clinical course is unpredictable, has a high rate of recurrence, and even can metastases and transform to a malignant tumor. Histological features of the tumor often could not predict its future biologic behavior, so it is just called ''Giant cell tumor'' without indicating maligna...

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