in this study, the effect of lovastatin and fluvastatin was compared with placebo in patients with high levels of total cholesterol and low density lipoprotein cholesterol (ldl-c) on the plasma lipid profile. in a prospective single blind clinical trial with convenient sampling, 120 hypercholesterolemic men and women with tcholesterol ≥220 mg/dl, ldl-c ≥ 160 mg/dl, and triglyceride ≤ 350 mg/dl ...

Reducing low-density lipoprotein cholesterol (LDL-C) levels does not eliminate cardiovascular risk; most patients obtain only a 25% to 35% risk reduction. When the triglyceride level is above 200 mg/dL, non–high-density lipoprotein cholesterol (non–HDL-C) is a more precise therapeutic target than LDL-C. It can serve as an excellent proxy for assessing the total number of circulating atherogenic...

The aim of the present study was to compare the effects of atorvastatin and pravastatin on lipid parameters and the concentration of malondialdehyde-modified low-density lipoprotein (MDA-LDL) in hypercholesterolemic patients. A total of 17 patients (10 men, 7 women; mean age, 68+/-9 years) who were indicated for drug therapy based on the National Cholesterol Education Program II underwent an 8-...

Very low-density lipoprotein (VLDL) receptor is a member of the low-density lipoprotein (LDL) receptor family. It binds triglyceride rich lipoprotein (TGRL) but not LDL, because it recognizes apolipoprotein (apo)E only but not apoB. The VLDL receptor functions as a peripheral lipoprotein receptor in concert with lipoprotein lipase (LPL) in heart, muscle, adipose tissue and macrophages. In contr...

Plasma very low density lipoprotein (VLDL) cholesterol and triglyceride, low density lipoprotein (LDL) cholesterol and triglyceridea, high density lipoprotein (HDL) cholesterol, glucose and insulin response (sums of 1- and 2-hour postload oral glucose levels), body mass index (BMI), and blood pressure were determined in a representative sample (n = 542) of the adult Israeli Jewish population. P...

Lipoprotein triglyceride and cholesterol concentrations and characteristics are described in normolipidemic and in three categories of hyperlipidemic subjects participating in the Pacific Northwest Bell Telephone Company Health Survey. For this study, 350 white participants 20 to 59 years of age with cholesterol or triglyceride values exceeding the age, sex, and hormone-use specific, population...