To determine the genetic contribution to variation among lipoprotein cholesterol levels, we performed quantitative trait locus (QTL) analyses on an intercross between mouse strains RIIIS/J and 129S1/SvImJ. Male mice of the parental strains and the reciprocal F1 and F2 populations were fed a high-cholesterol, cholic acid-containing diet for 8-12 wk. At the end of the feeding period, plasma total...

BACKGROUND In an attempt to map the genes predisposing to the common, complex aetiologies of end-stage renal disease (ESRD), we performed a genome-wide scan in 1023 individuals with chronic kidney disease (946 dialysis dependent and 77 with advanced chronic renal failure) from 483 African American families. METHODS The study sample comprised 563 ESRD-affected sibling pairs, with nephropathy a...

In genetic analysis of diseases in which the underlying model is unknown, "model free" methods-such as affected sib pair (ASP) tests-are often preferred over LOD-score methods, although LOD-score methods under the correct or even approximately correct model are more powerful than ASP tests. However, there might be circumstances in which nonparametric methods will outperform LOD-score methods. R...

The recognition of the blood group system called Dombrock was reported in 1965 by Swanson and her colleagues. In 1967 Tippett gave an account of the genetics of the system which included an analysis of the linkage relations of the Do locus to other blood group loci, based on families tested in the MRC Blood Group Unit up to April 1966. The present account brings the linkage analysis up to the e...

Contrails are clouds caused by airplane exhausts, which geologists contend decrease daily temperature ranges on Earth. Following the 2001 World Trade Center attack, cancelled domestic flights triggered the first absence of contrails in decades. Resultant exceptional data capacitated causal inference analysis by propensity score matching. Estimated contrail effect was 6.8981°F.

The LOD cloud is gathering a lot of momentum, with the number of contributors growing manifold. Many prominent data providers have submitted and linked their data to other dataset with the help of manual mappings. The potential of the LOD cloud is enormous ranging from challenging AI issues such as open domain question answering to automated knowledge discovery. We believe that there is not eno...

The datasets that are part of the Linking Open Data cloud diagramm (LOD cloud) are classified into the following topical categories: media, government, publications, life sciences, geographic, social networking, user-generated content, and cross-domain. The topical categories were manually assigned to the datasets. In this paper, we investigate to which extent the topical classification of new ...

Publishing agro-environmental resources to a linked open data (LOD) cloud requires publishers to adopt a set of universally recognized linked data principles. These principles, along with semantic annotations based on shared domain ontologies can ensure the semantic integration of agro-environmental resources. In this paper we present a resource-publishing system, called AGROPub, that we develo...

Taking precautions before a disaster to reduce the causalities and losses engendered by natural disasters is relatively cheaper, and more importantly, better than cure. The authors propose a conceptual framework with the consideration of all stakeholders related to the disaster management to have a better risk management, and to guide the design, implementation and integration of the 3D urban m...

This paper considers the extension of a real-time graphics renderer to support fovea enhancement|the technique of localising visual detail to the particular region of the display which the user is looking towards. This is performed by extending the standard notion of distance Level of Detail (LOD) into three dimensions to give volu-metric LOD; whereby the LOD of an object is related to its pres...