Diabetic kidney disease is the leading cause of end-stage renal disease. Podocytes are differentiated cells necessary for the development and maintenance of the glomerular basement membrane and the capillary tufts, as well as the function of the glomerular filtration barrier. The epithelial glomerular cells express a local renin-angiotensin system (RAS) that varies in different pathological sit...

During the last four decades, the renin–angiotensin system (RAS) has emerged as an important endocrine factor in the chain of physiological blood pressure regulation and water–electrolyte balance, and as a substantial determinant of cardiovascular and renal remodelling. For >20 years it has been established that angiotensinogen is produced in the liver, and is in turn cleaved by the proteolytic...

information has numerous potentials and features by which it can be used in various aspects of society. this paper aims to examine some roles and unique characteristics of information and supports the theory that information can be treated as wealth or wealth creator due to its vital impacts. finally, it is shown that identifying information significance, the roles it plays and making better us...

A case of extramammary Paget's disease of the axilla in an 84-year-old patient is presented. No underlying carcinoma was found and the lesion was treated successfully by wide local excision. Immunohistochemical staining showed nuclear immunoreactivity for c-myc and cytoplasmic staining for CEA, EMA, CAM 5.2, EGRF, c-erbB-2 and pan-cytokeratin in all the Paget cells. No immunoreactivity of the l...

Introduction: The aim of this study was to evaluate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in patients with recurrent aphthous stomatitis (RAS).   Materials and Methods: Eighty patients who were diagnosed with RAS between January 2014 and January 2016 were included in this study. Eighty age- and gender-matched healthy subject...

In human carcinomas, stromelysin-3/matrix metalloproteinase 11 (ST3, MMP11) expression by nonmalignant fibroblastic cells located in the immediate vicinity of cancer cells is a bad prognostic factor. Using mouse models of primary tumors, it has been demonstrated that ST3 is a key player during local invasion, favoring cancer cell survival in connective tissue through an antiapoptotic function. ...

Abstract DKI Jakarta is the capital city of Indonesia well known as a with most rapid development and growth in country. This indicates that increase population Jakarta, need for considerable change land use cannot be denied. Environmental problems will get worse over time have resulted flooding which has been concern local government every year. A polder system stated to effective resolving fl...

nowadays programming and designing of green space of urban area, without considering the criteria for 'optimum standards of green areas is impossible, . in this research, it is tried to determine, the per capita standard rate of green space in different regions of gorgan city, . the applied methedology is an integration of several international and local methods, based on the principles of...

PURPOSE To review current literature on the renin-angiotensin system (RAS)-mediated pathogenic mechanisms and therapeutic targets in ocular diseases. METHODS A comprehensive literature survey was performed on PubMed, Scopus, and Google Scholar databases published from 1977 to 2016. The search terms were a RAS, angiotensin, angiotensin receptor, prorenin, pro (renin) receptor, angiotensin conv...