Monoclonal antibodies specific for the rod region can affect smooth muscle myosin's motor properties. Actin movement by phosphorylated myosin was inhibited by an antibody (LMM.4) which binds to the COOH-terminal end of the coiled-coil rod, a region thought to be involved in filament assembly. The actin-activated ATPase activity of the myosin-antibody LMM.4 complex was also reduced 10-fold at ac...

utaneous foot melanoma is rare; it accounts for approximately 1% of all cutaneous melanoma and can be challenging to manage [1]. There are four main variants of cutaneous malignant melanomas (CMMs), superficial spreading melanoma (SSM), lentigo malignant melanoma (LMM), nodular melanoma (NM) and acral lentiginous melanoma (ALM). Superficial spreading melanoma accounts for approximately 65% of a...

This paper discusses the use of Linear Mixed Models (LMM) and Generalized Linear Mixed Models (GLMM) to predict the wear and damage trajectories of railway wheelsets for a fleet of modern multiple unit trains. The wear trajectory is described by the evolution of the wheel flange thickness, the flange height and the tread diameter; whereas the damage trajectory is assessed through the probabilit...

Mobile IPv6 (MIPv6) and Fast Handover (FHO) have been developed by the Internet Engineering Task Force (IETF) to address the IP mobility issues of roaming mobile devices, and to reduce handover latency due to link switching delay, movement detection and IP address configuration during MIPv6 operation, respectively. In an attempt to enhance the performance of MIPv6, the Hop-byHop Local Mobility ...

Most of the approaches to solve the unmixing problem are based on the Linear Mixing Model (LMM) which is questionable. Therefore, nonlinear spectral model is generally used to study the effects of multiple scattering in the complex surfaces. In this paper, we have demonstrated the application of Radiative Transform Equation (RTE) based Hapke multi scattering model. The Hapke model based non-lin...

Methylmercury (MeHg) is a neurotoxin formed from inorganic divalent mercury (HgII) via microbial methylation, and boreal wetlands have been identified as major sources of MeHg. There however lack studies investigating the relationship between chemical speciation HgII MeHg formation in such environments, particular regarding to role thiol compounds. We determined methylation potentials, kmeth, w...

Motivation: Amongst the many model-based approaches to modeling object classes, the Linear Morphable Model is an important one (Vetter and Poggio [6], Jones and Poggio [2]). It has been been used successfully to model faces, cars and digits. In these applications, the task of matching a novel image to the LMM is achieved through a computationally intensive analysis by synthesis approach. In Jon...

In this paper, we consider the nonlinear system modelling problem for on-chip testing and diagnosis of embedded mixed-signal systems. A SituationDependent AutoRegressive model with eXogenous variable (SDARX) is introduced to approximate the conventional Nonlinear-ARX (NARX). The parameter search space is divided into a linear weight subspace and the nonlinear parameter subspace. A nonlinear par...

This paper studies survival measures in credit risk models. Survival measure, which was first introduced by Schönbucher [12] in the framework of defaultable LMM, has the advantage of eliminating default indicator variable directly from the expectation by absorbing it into Randon-Nikodym density process. Survival measure approach was further extended by Collin-Duresne [4] to avoid calculating a ...

Background: The European Working Group on Sarcopenia in the Elderly defined sarcopenia as a geriatric syndrome with diagnostic criteria of low skeletal muscle mass (LMM). Various consensuses recommend cut-offs for LMM, use below 2 SDs from mean index (SMI) young reference group. Given contrast between reported cut-offs, objective this study was to establish LMM older...