BACKGROUND Renal transplantation is the ideal method for management of end-stage renal disease. The use of living donors for renal transplantation was critical for early development in the field and preceded the use of cadaveric donors. Most donors are related genetically to the recipients, like a parent, a child, or a sibling of the recipient, but there are an increasing percentage of cases wh...

The United States and most other nations suffer from a shortage of human organs for transplant. In the United States, over 120,000 people are on waiting lists for organ transplant and every year over 10,000 people die while waiting (Organ Procurement and Transplantation Network). There are a number of fronts on which research has made progress to address this shortage, but there is still signif...

BACKGROUND Intermittent hepatic inflow occlusion (IHIO) is associated with acute hyperglycemia during living donor hepatectomy when the ischemia is prolonged. Bilirubin is a potent antioxidant to play an important role for maintaining insulin sensitivity and preventing hyperglycemia. Thus, we aimed to test whether serum bilirubin level is associated with prolonged IHIO-induced intraoperative hy...

OBJECTIVE To analyse the effects of baseline body mass index (BMI) on the postoperative and remote consequences of nephrectomy in living kidney donors, as body weight is conventionally used as an exclusion criterion for kidney donation and a BMI of <35 kg/m(2) is often required. PATIENTS AND METHODS We retrospectively studied 189 living-related kidney donors who had their nephrectomy between ...

Growing incidence of end-stage renal disease, shortage of kidneys from deceased donors and a better outcome for recipients of kidneys from living donor have led many centres worldwide to favour living donor kidney transplantation programmes. Although criteria for living donation have greatly evolved in recent years with acceptance of related and unrelated donors, an immunological incompatibilit...

The gap between the growing demand for available organs and the cadaveric organs facilitates the adoption of living donor liver transplantation. We retrospectively identified and evaluated the post-operative complications as per the modified Clavien classification system in 152 living liver donors at at the First Affiliated Hospital, College of Medicine, Zhejiang University between December, 20...

Between June, 1984 and January 20, 1987, 69 kidney transplantations were performed in our department. All kidneys were acquired from living donors. 63% of the cases were high-risk MLC-positive (poorly matched), and all but one were from related sources. There were only five rejected kidneys, all of which occurred in kidneys from parent donors. 28 recipients received donor-specific transfus...

After the first successful living donor kidney transplant between identical twins at Harvard in 1954, Joseph Murray, who received the Nobel prize, said of the recipient’s famed nephrologist ‘John Merrill and I had an understandable difference of opinion as to whether or not native kidneys (from healthy living donors) should be removed’ (1). In the subsequent 6 decades, the controversies over re...

Living organ donors frequently incur non-medical expenses for travel, accommodation, prescription drugs, loss of income, and child care in conjunction with organ donation. Despite international precedent and widespread public support, Canada currently lacks a unified strategy to reimburse donors for these expenses. In 2005, we communicated with 78 individuals within the field of Canadian transp...

Adult-to-adult living donor liver transplantation (LDLT) is being performed in the United States with increasing frequency because of the severe shortage of cadaveric donor organs.1,2 For example, 42 of 89 Organ Procurement and Transplantation Network– certified liver transplant programs (47%) reported having performed at least one adult-to-adult LDLT in 2000, and 355 adult-to-adult LDLTs were ...