The aim of this study was to investigate acute toxicity (96-hr LC50 and lethal concentrations) of waterborne metal mixture (Pb+Mn) for the fish, Catla catla, Labeo rohita, Cirrhina mrigala, Ctenopharyngodon idella and Hypophthalmichthys molitrix. The extent of metals bio- accumulation in fish body organs viz. gills, liver, kidney, fins, bones, muscle and skin at both 96-hr LC50 and lethal conce...

BACKGROUND Concomitant pulmonary and hepatic toxicity secondary to nitrofurantoin is a rare but serious complication of the use of Nitrofurantoin. CASE PRESENTATION A 72 year old woman taking Nitrofurantoin for recurrent urinary sepsis presenting with breathlessness abdominal discomfort and abnormal liver function tests is described. Drug toxicity secondary to Nitrofurantoin was diagnosed. Ce...

Understanding the mechanism of chemical toxicity, which is essential for cross-species and dose extrapolations, is a major challenge for toxicologists. Standard mechanistic studies in animals for examining the toxic and pathological changes associated with the chemical exposure have often been limited to the single end point or pathways. Toxicoproteomics represents a potential aid to the toxico...

In this research work, 2, 4-substituted oxazolone derivatives OXZ-1 to OXZ-5 were screened for antidiabetic activity at 200 and 400 mg/kg b.w. p.o. for 15 days in streptozotocin induced diabetic rats. Acute and sub-acute toxicity studies were performed as per OECD guideline Up and Down Procedure425 and 407. Clinical signs, body weight, hematological, biochemical and histopathological examinatio...

OBJECTIVE To assess the feasibility of a new method of measuring the attenuation coefficient in the liver, which offers less variability of results than the conventional method. METHODS The attenuation coefficient was evaluated on the basis of the following equation with sound field correction: [log(M0 (z)) - tau(z)]. In our system, the attenuation coefficient was also evaluated by the spectr...

Explanation.................................................................................................. 189 Evaluation for acceptable daily intake......................................................... 190 Biochemical aspects ......................................................................... 190 Absorption, distribution and excretion ....................................... 190 Me...

Background: Mentha longifolia is one of the aromatic medicinal plant belongs to Lamiaceae family. There are some active ingredients in the essential oil of M. longifolia, which potentially could impair the hepatic function. The aim of this study was to find the maximum dose of essential oil of M. longifolia (EOML) that does not show any hepatic deterioration. Methods: Adult Wistar rats fed d...

Background: Bisphenol A (BPA) has received attention in environmental and toxicological research due to its widespread effects in biological systems. While several anti-oxidants have been used in ameliorating BPA-induced toxicities in experimental animals, there is the scarcity of research information on the use of Gallic acid (GA) in protecting against BPA-induced toxicity. This study investig...