Pulmonary alveolar proteinosis is a disease caused by increased accumulation and impaired clearance of surfactant by alveolar macrophages. This narrative review summarizes the role of therapeutic whole-lung lavage in the management of pulmonary alveolar proteinosis. We describe the preprocedural evaluation, indications, and anesthetic considerations, along with step-by step technical aspects of...

BACKGROUND Pulmonary alveolar proteinosis is an extremely rare lung disease in animals and humans. It is characterized by the deposition of a large amount of phospholipoproteinaceous material in the alveoli. There are several possible etiologies, both congenital and acquired. Alveolar macrophages play an important role in the clearance of surfactant. This is the first report of pulmonary alveol...

lipoid congenital adrenal hyperplasia (lipoid cah), a rare disorder of steroid biosynthesis, is the most severe form of cah. in this disorder the synthesis of glucocorticoids, mineralocorticoids and sex steroids is impaired which result in adrenal failure, severe salt wasting crisis and hyperpigmentation in phenotypical female infants irrespective of genetic sex. in this report, we presented a ...

Nieuwland et al. (2017, http://biorxiv.org/content/early/2017/02/25/111807) recently made available their (thus far to our knowledge) unpublished manuscript, describing a nine-lab replication attempt of DeLong, Urbach and Kutas (2005), hereafter DUK05. They concluded that over their nine labs, the a/an Article prediction effect reported in DUK05 did not replicate. Here, we highlight some featur...

Pulmonary alveolar proteinosis is a rare cause of respiratory distress in neonates. We present a 4 month old infant who presented with progressive respiratory distress since birth and failure to thrive. He was initially treated as a case of diffuse alveolar disease but on open lung biopsy was diagnosed as pulmonary alveolar proteinosis. The child expired at 7 months of age.

Pulmonary alveolar proteinosis is characterized by excessive accumulation of surfactant-like material in the alveoli, resulting in part from defective alveolar clearance by macrophages. We present a case of alveolar proteinosis in a patient with malignant melanoma metastatic to lung and discuss possible alteration in macrophage function in the pathogenesis of these two concomitant processes.

Kirby (1994) has helpfully applied the terminology of signal detection theory to Watson's selection task. We agree with him that it is necessary to bring out the decision theoretic aspects of the selection task (Evans, Over & Manktelow, 1993), and Kirby makes an important contribution by doing this so fully for an abstract version of the task. However, there are problems with both the design of...

A paradigmatic example of an emotional bias in decision making is the framing effect, where the manner in which a choice is posed--as a potential loss or a potential gain--systematically biases an ensuing decision. Two fMRI studies have shown that the activation in the amygdala is modulated by the framing effect. Here, contrary to an expectation based on these studies, we show that two patients...

A 9 year old boy with juvenile dermatomyositis developed pulmonary alveolar lipoproteinosis. This previously unreported association was treated successfully by bronchoalveolar lavage.

Background : Lipoid pneumonia is a rare disease and usually reported as sporadic cases. Exogenous lipoid more common form of pneumonia. Untypical characteristics makes incidence rate this cases are often imprecise. The diagnosis made from history lipid containing material aspiration, radiologic imaging, histopathological examination. There no treatment choice because rarely made.
 Case Rep...