Abstract Background and Aims Chronic kidney disease (CKD) is an urgent public health issue in the world. However, effective treatments for intervention of CKD remain undefined. Phosphate (Pi) essential element synthesis DNA, RNA, ATP, phospholipid membranes, regulation phosphorylation/dephosphorylation, cellular signaling metabolic pathways. Solute carrier family 34 (SLC34) responsible Pi absor...

Objective: Currently there is no cure for cystic fibrosis (CF) disease and lung the most affected organ [1Cooney A Gene. 2018 Nov; 9: 538Crossref Scopus (72) Google Scholar]. Gene replacement a promising strategy to treat this disease. However, two big challenges that have impeded its success are absence of: (1) an efficient safe gene delivery reagent transfect target cells, (2) stable plasmid ...

Background: Human papillomavirus (HPV) is responsible for the development of cervical neoplasia.  Infection with human papillomavirus type 16 (HPV-16) is a major risk factor for the development of cervical cancer. The virus encodes three oncoproteins (E5, E6 and E7), of which, the E7 oncoprotein is the major protein involved in cell immortalization and transformation o...

Background: Strategies aimed at inhibiting the expression of c-myc oncogene could provide basis for alternative cancer treatment. In this regard, silencing using small interfering RNA (siRNA) is an attractive option. However, development a clinically viable, siRNA-based, system largely dependent upon design appropriate siRNA carrier that can ...

background: human papillomavirus (hpv) is responsible for the development of cervical neoplasia.  infection with human papillomavirus type 16 (hpv-16) is a major risk factor for the development of cervical cancer. the virus encodes three oncoproteins (e5, e6 and e7), of which, the e7 oncoprotein is the major protein involved in cell immortalization and transformation of the infected cells. the ...

Objective(s): The OCT4B1, as one of OCT4 variants, is expressed in cancer cell lines and tissues more than other variants and plays an important role in apoptosis and stress (heat shock protein) pathways. The present study was designed to determine the effects of OCT4B1 silencing on expressional profile of HSP40 gene family expression in three different human tumor cell lines. Materials and Met...

Background: OCT4B1, a variant of OCT4, is expressed in both cancer cells and tissues. This variant has a main role in the regulation of both apoptotic and stress (heat-shock proteins) pathways. The aim of this study was to investigate the effects of OCT4B1 silencing on the expression of small heat-shock proteins (sHSPs)in three human tumor cell lines. Methods:...