introduction: intracellular ph (phi) regulates essentially all aspects of cellular activities. however, it is unknown how endoplasmic reticulum (er) potassium channels sense phi. in this study, we investigate the direct effects of phi on er potassium channels. methods: we used channel incorporation into the bilayer lipid membrane method. l-α-phosphatidylcholine, a membrane lipid, was extracted ...

abstract introduction: several studies demonstrated association between dislipidemia and psychiatric disorder. the aim of this study is evaluation of the lipid profile of patient with comorbid generalized anxiety disorder and major depressive disorder. method: this is a descriptive- analytic study of 100 patient (25 in major depressive disorder, 25 in generalized anxiety disorder, 25 in comorbi...

objective(s): bone marrow mesenchymal stem cells (mscs) play an important role in bone health. cadmium causes osteoporosis, but the exact mechanisms of its effect on mscs are not known. materials and methods: rats were treated with cadmium chloride (40 mg/l) in drinking water for six weeks, and then the biochemical and morphological studies on mscs were carried out as a cellular backup for oste...

oxidation of low density lipoprotein (ldl) particles plays a key role in the etiology of atherosclerosis and coronary artery disease (cad). oxidative stress enhances the likelihood of ldl oxidation and atherosclerotic plaque development. paraoxonase (poni) is an enzyme associated with hdl that metabolizes organophosphates and has antioxidant activity. in order to investigate the relationship be...

background: the exact pathophysiology of testicular degeneration, following varicocele has not been completely understood yet.   objective: the current study was designed to determine the effect of varicocele on germinal epithelium (ge) cytoplasmic biohistochmical alterations.   materials and methods: to follow-up this study, left varicocele was induced in test groups. non-varicocelized rats we...

conclusions these results demonstrate that the hypolipidemic and antioxidative effects of aqueous extract of e. caryophyllus might be due to its ability to ameliorate lipid profiles, enhance antioxidant activities, and delay the lipid peroxidation process. this confirms the previously identified protective roles of e. caryophyllus in human health. background eugenia caryophyllus (clove) is an i...

introduction: ramadan is a holy month for muslims during which avoid from eating, drinking and sexual intercourse for about 13-17 hours. the aim of this study was surveying the effects of islamic fasting in ramadan on lipid profile and blood pressure.materials and methods: we designed this study in two phases, a week before and a week after ramadan month. eighty nine healthy subjects with 20-50...

conclusions we observed no significant differences between the two groups in lipid and carbohydrate metabolism, except for hdl-c. considering the importance of overweight and obese women’s health, studies with longer follow-up periods are recommended in this respect. results the differences in lipid and carbohydrate parameters were not significant between the two groups, except for hdl-c (adjus...

objectives:hypertension is one of the most common diseases of the modern era. this study evaluates the effect of hydro-alcoholic celery leaf extract onsystolic blood pressure (sbp), heart rate (hr) and lipid profile in animals’ model of hypertension induced by fructose. materials and methods: sprague dawley rats were divided into five groups: 1) control group (free access to tap drinking water)...