Quantitative results are reported for gas-liquid chromatography of mixtures of free tetra-, hexa-, and octadecanals and cis-9-octadecenal on polar and nonpolar liquid phases. Stability of the fatty aldehydes during chromatographic analysis and up to 1 year of storage appears to be related to the solvent (carbon disulfide) used. Analysis of the free aldehydes by gas-liquid chromatography elimina...

objective: the aim of this study was to evaluate the effect of good glycemic control on serum lipids levels and lipid peroxidation, and to find out the relationship between the level of malondialdehyde and hba1c in type 2 diabetes. materials and methods: fifty type 2 diabetic patients aged 40-60 years with the history of diabetes for more than 10 years were studied. glycemic control was stable ...

The synthesis of some new 1,3,4-oxadiazole derivatives and 1,2,4-triazine-5-one has been described. IR, H NMR and mass spectral data support the structures of newly synthesized compounds. All the compounds have been tested in vivo for their anti-inflammatory activity by carrageenin-induced rat paw edema method. The compounds, which show good antiinflammatory activity, have been screened for the...

Brain lipids are integral components of brain structure and function. However, only recent advancements of chromatographic techniques together with mass spectrometry allow comprehensive identification of lipid species in complex brain tissue. Lipid composition varies between the individual areas and the majority of previous reports was focusing on individual lipids rather than a lipidome. Herei...

Lipid droplets (LDs) are ubiquitous and physiologically active organelles regulating storage and mobilization of lipids in response to metabolic demands. Among the constituent LD neutral lipids, such as triacylglycerols, cholesterol esters, and free fatty acids, oxidizable polyunsaturated molecular species may be quite abundant, yet the structural and functional roles of their oxidation product...

Most of the new chemical entities discovered today are highly lipophilic in nature and show poor solubility and membrane permeability resulting in poor oral bioavailability. The need for an effective carrier system led to the development of novel lipid based carriers for enhancing the solubility and bioavailability of such drugs Lipids are fatty acids and their derivatives, and substances relat...

Lipids are essential components of a living organism as energy source but also as constituent of the membrane lipid bilayer. In addition fatty acid (FA) derivatives interact with many signaling pathways. FAs have amphipathic properties and therefore require being associated to protein for both transport and intracellular trafficking. Here we will focus on several FA handling proteins, among whi...

Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer and inflammation models. The pathophysiological role of linoleic acid- arachidonic acid-derived ALOX15 metabolites rendered this enzyme a target for pharmacological research. Several indole imidazole derivatives inhibit the catalytic activity rabbit substrate-specific manne...