BACKGROUND AND PURPOSE Transfusion of large polymers of hemoglobin avoids the peripheral extravasation and hypertension associated with crosslinked tetrameric hemoglobin transfusion and may be more effective in rescuing brain from focal ischemia. Effects of transfusion of high-oxygen-affinity hemoglobin polymers of different weight ranges were determined. METHODS Hypervolemic exchange transfu...

Joint damage and disability in rheumatoid arthritis (RA) both increase with disease duration but the nature of their relationship is uncertain. This review updates knowledge of the progression and inter-relationship of joint damage and disability in treated RA and provides a synopsis of the main predictive factors for damage and disability. In early RA 39-73% of patients develop one or more ero...

PURPOSE To investigate the possibility of measuring the gene-specific DNA damage after therapeutic exposure to nitrogen mustards and to examine its relationship with the clinical response. EXPERIMENTAL DESIGN The kinetics of gene-specific monoadducts and interstrand cross-link formation/repair were measured in the p53 and N-ras genes. DNA extracted from human peripheral lymphocytes following ...

A new brittle-elastoviscoplastic (BEVP) fluid model is presented in this paper. This relatively simple to use, as it contains few material parameters and a fixed-point algorithm effective for solving the coupled system of equations. The combines some existing fundamental features such elasticity, plasticity brittle damage. combination them based on thermodynamics that ensures positivity dissipa...

The response to and repair of DNA damage are central to our understanding of the causes of breast cancer. DNA damage results from environmental exposure to genotoxic agents, lifestyle factors, and cellular metabolism. Among the most lethal forms of DNA damage are double-strand breaks. A failure to accurately repair double-strand breaks has catastrophic consequences for the cell, including aneup...

This paper presents an application of Continuum (i.e. Lagrangian) and Finite Element Techniques to flexible manipulator arms for derivation of the corresponding Dynamic Equations of Motion. Specifically a one-link flexible arm is considered for detailed analysis, and the results are extended for the case of a two - link flexible manipulator. Numerical examples are given for the case of both one...

We address the following problem: Given a simple polygon $P$ with $n$ vertices and two points $s$ and $t$ inside it, find a minimum link path between them such that a given target point $q$ is visible from at least one point on the path. The method is based on partitioning a portion of $P$ into a number of faces of equal link distance from a source point. This partitioning is essentially a shor...

The biological processes that underlie senescence are of universal biological importance, yet they remain poorly understood. A popular theory proposes that senescence is the result of limited investment into mechanisms involved in the prevention and repair of molecular damage, leading to an accumulation of molecular damage with age. In ants, queen and worker lifespans differ by an order of magn...