Relations between the frequency map of a generic Hamiltonian model, describing the vibrational dynamics of the LiNC/LiCN molecular system, and its chaotic behavior are discussed. The scaling structure of the local frequency map is studied based on the multifractal analysis. This approach allows different behaviors to be recognized as well as to study the evolution of the molecular system at dif...

This qualitative case study discusses a personal experience of using several online activities with a group of adult students. The study illustrates how an online environment can supplement face-to-face teaching to produce greater significant learning experience for students. The online environment was based on using open source learning management systems. The study examines a group of post gr...

Hereditary hearing loss is the most common sensory deficit. We determined that progressive high-frequency hearing loss in 2 families of Iraqi Jewish ancestry was due to homozygosity for the protein truncating mutation SYNE4 c.228delAT. SYNE4, a gene not previously associated with hearing loss, encodes nesprin-4 (NESP4), an outer nuclear membrane (ONM) protein expressed in the hair cells of the ...

Nuclear positioning is a crucial cell function, but how a migrating cell positions its nucleus is not understood. Using traction-force microscopy, we found that the position of the nucleus in migrating fibroblasts closely coincided with the center point of the traction-force balance, called the point of maximum tension (PMT). Positioning of the nucleus close to the PMT required nucleus-cytoskel...

Most work on determiners has been concerned with purely semantic properties, the occurrence of particular determiners in certain syntactic environments such as existential-there sentences, determiners as heads of phrases (the DP hypothesis, Abney 1987) or quantifier scoping. One question that has not been extensively discussed in the literature is how the various English determiners order with ...

The linker of nucleoskeleton and cytoskeleton (LINC) complex is situated in the nuclear envelope and forms a connection between the lamina and cytoskeletal elements. Sun1, Sun2 and nesprin-2 are important components of the LINC complex. We expressed these proteins fused to green fluorescent protein in embryonic fibroblasts and studied their diffusional mobilities using fluorescence recovery aft...

Primary and acquired drug resistance is one of the main obstacles encountered in high-grade serous ovarian cancer (HGSC) chemotherapy. Cisplatin induces DNA damage through cross-linking and long integrated non-coding RNAs (lincRNAs) play an important role in chemical induced DNA-damage response, which suggests that lincRNAs may be also associated with cisplatin resistance. However, the mechanis...

Changes in blood flow regulate gene expression and protein synthesis in vascular endothelial cells, and this regulation is involved in the development of atherosclerosis. How mechanical stimuli are transmitted from the endothelial luminal surface to the nucleus is incompletely understood. The linker of nucleus and cytoskeleton (LINC) complexes have been proposed as part of a continuous physical...