background: scleroderma is a chronic connective tissue disease of unknown etiology. vitamin d and parathyroid hormone (pth) that play particular functions in calcium and phosphate homeostasis may be involved in the etiology of this disorder. klotho, the co-receptor of the fibroblast growth factor 23 (fgf-23), can interfere with calcium and phosphate metabolism. the purpose of this study was to ...

Scleroderma renal crisis has been documented as the presenting manifestation of systemic sclerosis sine scleroderma in pregnancy only once in the literature. Unfortunately, since scleroderma renal crisis in sine scleroderma pregnant patients is so rare, that patient expired. We present a case of a sine scleroderma pregnant patient with an initial manifestation of scleroderma renal crisis surviv...

Background Deficiency of adenosine deaminase 2 (DADA2) is a rare monogenic autoinflammatory disease characterized by the presence systemic inflammation, vasculitis, early-onset stroke, and hematologic manifestations such as cytopenia immunodeficiency. Mucocutaneous peripheral microvascular manifestations, livedo racemosa, cutaneous ulcers Raynaud’s phenomenon (RP), can occur, in up to 50%, 22% ...

The article presents a clinical case of rare onset and special course juvenile scleroderma. A child who was born lives in the ecologically unfavorable industrial Donetsk region is described. literature review influence environment on morbidity features autoimmune pathology patients offered. In particular, indicates that negative environmental factors lead to an increase progression systemic scl...

Eosinophilic fasciitis (EF) often is confused with scleroderma. A 50-year-old woman presented with progressive tightening of the skin of the arms and legs. She complained of diffuse joint pain that was prominent in the hands and wrists. Her past medical history was significant for hypothyroidism. A skin biopsy revealed superficial and deep infiltrates of inflammatory cells with eosinophils. Phy...

To cite: Bonnecaze AK. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2015-212911 DESCRIPTION A 41-year-old African American woman with no significant medical history presented to clinic reporting of episodic finger numbness and colour changes. She described feeling as if her fingers were frostbitten and noted her second, third and fourth digits appeared white d...

BACKGROUND Scleroderma is a clinically heterogeneous disease with a complex phenotype. The disease is characterized by vascular dysfunction, tissue fibrosis, internal organ dysfunction, and immune dysfunction resulting in autoantibody production. METHODOLOGY AND FINDINGS We analyzed the genome-wide patterns of gene expression with DNA microarrays in skin biopsies from distinct scleroderma sub...

Background: Scleroderma is a chronic systemic disorder that affects the connective tissues. It is characterized by several immune manifestations, inflammation, vascular damage, and fibrosis. Some of the viral infections with complex mechanisms are involved in the development and progression of many autoimmune diseases, such as scleroderma. The present study aimed to investigate the serological ...

A 56-year-old woman presented with long-standing pain in both knees. She had been suffering from Raynaud’s phenomenon for 10 years. A physical examination showed hard subcutaneous nodules on the extensor surfaces of both knees and elbows (Picture 1: left elbow and right knee) with sclerodactyly and telangieclagia in both hands. The Creactive protein level was normal (0.08 mg/dL, normal < 0.3), ...