Previous studies have reported the production of malformed virus-like-particles (VLP) in recombinant host systems. Here we computationally investigate the case of a large triple-layered rotavirus VLP (RLP). In vitro assembly, disassembly and reassembly data provides strong evidence of microscopic reversibility of RLP assembly. Light scattering experimental data also evidences a slow and reversi...

We consider a directed random walk making either 0 or +1 moves and a Brownian bridge, independent of the walk, conditionned to arrive at point b on time T. The Hamiltonian is deened as the sum of the square of increments of the bridge between the moments of jump of the random walk and interpreted as an energy function over the bridge connguration; the random walk acts as the random environment....

We consider a directed random walk making either 0 or +1 moves and a Brownian bridge, independent of the walk, conditionned to arrive at point b on time T. The Hamiltonian is deened as the sum of the square of increments of the bridge between the moments of jump of the random walk and interpreted as an energy function over the bridge connguration; the random walk acts as the random environment....

The introduction of a modulus z(K), analogous to u = 〈trφ2〉 in the N = 2 SUSY SU(2) gauge theory solved by Seiberg and Witten, and whose defining property is the invariance under the symmetry and duality transformations of the effective coupling K, reveals an intriguing correspondence between the D = 2 Ising and Potts models on the square lattice. The moduli spaces of both models, the spaces of...

Ear candling is an alternative medicine practice alleged to enhance general health by putting an end of a hollow candle in the ear canal and lighting up the other end of it. It also is advertised for cerumen and debris (bacteria and fungi) removal. Ear candling is claimed to create negative pressure for drawing cerumen from the ear and to benefit the ears in many ways. It is however not free o...

A Highly efficient protocol has been developed for the synthesis of 2-hydrazolyl-4-thiazolidinone derivatives installing a one pot three component coupling reaction of an aromatic aldehyde, thiosemicarbazide and maleic anhydride using guanidine hydrochloride as highly inexpensive and environmentally friendly catalyst under solvent free condition at 1200C with good to excellent yields, It offers...