Plant genomes contain a large number of genes encoding for berberine bridge enzyme (BBE)-like enzymes. Despite the widespread occurrence and abundance of this protein family in the plant kingdom, the biochemical function remains largely unexplored. In this study, we have expressed two members of the BBE-like enzyme family from Arabidopsis thaliana in the host organism Komagataella pastoris. The...

Objectives: This study was designed to investigate the potential Phyllanthus niruri extracts in promotion of hair growth. Materials and Methods: Here, we studied the hair growth promoting activity of petroleum ether extract of P. niruri following its topical administration. Alopecia was induced in albino rats by subcutaneous administration of testosterone for 21 days. Evaluation of hair loss in...

Microtubule Affinity-Regulating Kinase 2 (MARK2) protein has a substantial role in regulation of vital cellular processes like induction of polarity, regulation of cell junctions, cytoskeleton structure and cell differentiation. The abnormal function of this protein has been associated with a number of pathological conditions like Alzheimer disease, autism, several carcinomas and development of...

The Front Cover shows that a medium-chain alcohol dehydrogenase modified in the loop is efficiently catalyzing N-Boc-3-pyrrolidone to produce (S)-N-Boc-3-pyrrolidinol. In their Research Article, H. Wang and co-workers proposed loop-loop interaction region acts like “bridges” between loops could be used adjust conformational dynamics of enzyme, thus modifying its catalytic efficiency. Combined w...

The presence of microbial load and high fiber content in various non conventional feedstuffs limit their utilization in poultry feed. In the present study, the feedstuffs were treated with acidified sodium chlorite (ASC) and its impact on  the microbial load and metabolizable energy availability was assessed in  the chickens. The effect of supplementation of feed grade enzyme was also evaluated...

microtubule affinity-regulating kinase 2 (mark2) protein has a substantial role in regulation of vital cellular processes like induction of polarity, regulation of cell junctions, cytoskeleton structure and cell differentiation. the abnormal function of this protein has been associated with a number of pathological conditions like alzheimer disease, autism, several carcinomas and development of...

An obese lady of 51 year with Type 2 Diabetes Mellitus for 13 years was prescribed Liraglutide, a glucagon like peptide (GLP-1) analogue (Victoza) for glycaemic control and reduction of weight. She was on gliclazide and Insulin prior to initiation of Liraglutide. Eight weeks after initiation of GLP -1 analogue, she developed severe abdominal pain, nausea and vomiting. She was admitted to a priv...