نتایج جستجو برای: lifespan
تعداد نتایج: 15331 فیلتر نتایج به سال:
A number of neurological diseases are caused by mutations of RNA metabolism-related genes. A complicating issue is that whether under- or overfunction of such genes is responsible for the phenotype. Polyglutamine tract binding protein-1, a causative gene for X-linked mental retardation, is also involved in RNA metabolism, and both mutation and duplication of the gene were reported in human pati...
BACKGROUND A laboratory inbred strain of the annual fish Nothobranchius furzeri shows exceptionally short life expectancy and accelerated expression of age markers. In this study, we analyze new wild-derived lines of this short-lived species. METHODOLOGY/PRINCIPAL FINDINGS We characterized captive survival and age-related traits in F1 and F2 offspring of wild-caught N. furzeri. Wild-derived N...
The RB pathway is one of the best-studied and most frequently altered pathways leading to loss of proliferative control in cancer. it can be disrupted by a variety of means including, but not limited to, epigenetic silencing, allelic loss or mutation of RB1. in some cancers including breast cancer, amplification of the CCND1 gene or overexpression of cyclin D1 is commonly observed.1 in others, ...
Life history theory predicts evolutionary trade-offs between investing in immune defense and other traits. We investigated whether reduced longevity was associated with increased investment in immunity in an avian brood parasite, the brown-headed cowbird (Molothrus ater). Previously we had found that the brown-headed cowbird was unusually resistant to infection with West Nile virus and other pa...
Lifespan of laboratory animals can be increased by genetic, pharmacological, and dietary interventions. Increased expression of genes involved in xenobiotic metabolism, together with resistance to xenobiotics, are frequent correlates of lifespan extension in the nematode worm Caenorhabditis elegans, the fruit fly Drosophila, and mice. The Green Theory of Aging suggests that this association is ...
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