We tested the hypothesis that inhibition of cutaneous sensory nerves would attenuate reflex cutaneous vasodilation in response to an increase in core temperature. Nine subjects were equipped with four microdialysis fibers on the forearm. Two sites were treated with topical anesthetic EMLA cream for 120 min. Sensory nerve inhibition was verified by lack of sensation to a pinprick. Microdialysis ...

Temporary deafferentation of the upper limb, with ischemic or anesthetic nerve block, has rapid effects on sensorimotor cortex. Cutaneous anesthesia of the forearm has recently been found to improve sensory and motor function of the paretic hand in chronic stroke patients. However, the neurophysiological mechanisms are unknown. The aim of this study was to investigate the behavioral and neuroph...

Chronic widespread pain and fibromyalgia often coexist with temporomandibular disorders (TMD) and affects mostly women. Studies have shown lower pressure pain thresholds (PPT) in these patients indicating that hyperalgesia is involved. The aim for this study was to investigate the effect of topical anesthesia on PPT for jaw muscles in patients with widespread pain. The hypothesis was that the P...

PURPOSE The aim of this study was to evaluate the effect of epinephrine (Epi) or felypressin (Fely) contained in dental local anesthetics on myocardial oxygen balance. MATERIALS AND METHODS Male Japanese White tracheotomized rabbits were anesthetized with isoflurane. Three doses of 0.18, 0.36, and 0.72 mL of 2% lidocaine hydrochloride containing 1:80,000 Epi or 3% prilocaine hydrochloride con...

BACKGROUND The initial placement of orthodontic elastomeric separators can be uncomfortable and painful. Therefore, it is important to relieve this disturbing sensation to create a discomfort or pain-free orthodontic visit. The purpose of this study was to investigate the effect of a lidocaine/prilocaine topical anesthetic on pain and discomfort associated with the placement of orthodontic elas...

BACKGROUND AND OBJECTIVES The purpose of this study was to compare the effectiveness of three local anesthetic agents for intravenous regional anesthesia in the upper limb. Side effects and plasma concentrations of the drugs in the doses administered for IVRA were also studied. METHODS Thirty patients in ASA groups I and II received intravenous regional anesthesia for surgery of the upper lim...

The purpose of this study was to examine the effects of various anesthetic methods to the level of pain felt by cancer patients during Chemoport needle insertion. The anesthetics evaluated were a topically-applied anesthetic cream (Lidocaine Cream), cryotherapy, and cutaneous stimulation. This study was based on non-equivalent control group design, A total of 120 subjects participated in the st...

Eutectic Mixture of Local Anaesthetics (EMLA) is recommended for use off-label as a treatment for premature ejaculation (PE). Other topical anaesthetics are available, some of which have been evaluated against oral treatments. The purpose of this systematic review was to evaluate the evidence from randomised controlled trials (RCTs) for topical anaesthetics in the management of PE. Bibliographi...