The potent antioxidants licorice root extract and glabridin, an isoflavan purified from licorice root extract, were tested for their ability to modulate the activities of several cytochrome P450 (P450) enzymes. P450 3A4, the major human drug metabolizing P450 enzyme, was inactivated by licorice root extract and by glabridin in a time-and concentration-dependent manner. The inactivation was NADP...

This article provides research to optimization of obtaining glycyrrhizic acid from dry extracts the licorice roots.Acid isolation was carried out two types extracts: 50% alcohol extract and aqueous extract.Glycyrrhizaglabra is a perennial plant, which can grow in various climatic conditions, including hot regions Kazakhstan. Stocks Kazakhstan are quite extensive estimated at several thousand to...

Coronary artery disease due to atherosclerosis is one of the highest killers today. Cholesterol level reduction by diet or medication would lead to either halting, or decreasing atherosclerosis. We examined whether Licorice root extract can halt atherosclerosis. Fifty male rabbits randomly were divided in five groups. They had gone under normal and high cholesterol (HC) diet for six weeks. One ...

Coronary artery disease due to atherosclerosis is one of the highest killers today. Cholesterol level reduction by diet or medication would lead to either halting, or decreasing atherosclerosis. We examined whether Licorice root extract can halt atherosclerosis. Fifty male rabbits randomly were divided in five groups. They had gone under normal and high cholesterol (HC) diet for six weeks. One ...

Licorice (Glycyrrhiza glabra L.) as a strategic and highly valuable medicinal plant in Iran with numerous beneficial pharmaceutical properties contributes substantially to Iranian herbs exports. In the present study, a variation on the phytochemical and antioxidant activity of 25 populations of valuable and profitable medicinal plant of G. glabra was investigated. The climate variables and soil...

Background and Objectives: Desiccation is a necessary procedure to eliminate moisture from foodstuffs in industries, especially pharmaceutical, food and tobacco industries. In the present study, a mathematical modeling was assessed for vacuum drying of the licorice roots. Materials and Methods: Fresh licorice roots were dried at 50 mbar. Temperatures included 22to 150°C and diameters of roots ...

Innumerable plants have been used widely as integral medicinal sources since the start of human civilization. The demand for herbal medicines is constantly increasing with time overtime. Licorice ( Glycyrrhiza glabra family Leguminosae) one most in foods, forms, and substantially researched on a worldwide scale. It was traditional complementary medicine against innumerable ailments including al...

Background and objectives: Up to present no efficacious antiviral medications have been discovered in order eradicate SARS-CoV-2 nasopharyngeal tract. In this article, the aim is evaluate effectiveness of a new herbal drug product called Aftogel patch, which contains licorice extract, eradication novel coronavirus secretions patients. Methods: triple-blind randomized clinical trial, 125 patient...

Treatment of melasma has remained a hottopic in dermatology because of its resistance totherapy and high recurrence rate. For many yearshydroquinone was the foundation of melasmatreatment, but its use has been limited during theseyears due to a number of adverse events, suchas skin irritation, hyper and hypo pigmentation,nail discoloration, conjunctival melanosis andochronosis. Furthermore hydr...