نتایج جستجو برای: lhermitte duclos disease

تعداد نتایج: 1490249  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Eric T Wang Greg Kodama Pierre Baldi Robert K Moyzis

By using the 1.6 million single-nucleotide polymorphism (SNP) genotype data set from Perlegen Sciences [Hinds, D. A., Stuve, L. L., Nilsen, G. B., Halperin, E., Eskin, E., Ballinger, D. G., Frazer, K. A. & Cox, D. R. (2005) Science 307, 1072-1079], a probabilistic search for the landscape exhibited by positive Darwinian selection was conducted. By sorting each high-frequency allele by homozygos...

Journal: :The Journal of clinical investigation 2013
You-Qiang Song Tatsuki Karasugi Kenneth M C Cheung Kazuhiro Chiba Daniel W H Ho Atsushi Miyake Patrick Y P Kao Kit Ling Sze Anita Yee Atsushi Takahashi Yoshiharu Kawaguchi Yasuo Mikami Morio Matsumoto Daisuke Togawa Masahiro Kanayama Dongquan Shi Jin Dai Qing Jiang Chengai Wu Wei Tian Na Wang John C Y Leong Keith D K Luk Shea-ping Yip Stacey S Cherny Junwen Wang Stefan Mundlos Anthi Kelempisioti Pasi J Eskola Minna Männikkö Pirkka Mäkelä Jaro Karppinen Marjo-Riitta Järvelin Paul F O'Reilly Michiaki Kubo Tomoatsu Kimura Toshikazu Kubo Yoshiaki Toyama Hiroshi Mizuta Kathryn S E Cheah Tatsuhiko Tsunoda Pak-Chung Sham Shiro Ikegawa Danny Chan

Lumbar disc degeneration (LDD) is associated with both genetic and environmental factors and affects many people worldwide. A hallmark of LDD is loss of proteoglycan and water content in the nucleus pulposus of intervertebral discs. While some genetic determinants have been reported, the etiology of LDD is largely unknown. Here we report the findings from linkage and association studies on a to...

2012
Ahmad Omair Benedicte Alexandra Lie Olav Reikeras Jens Ivar Brox

OBJECTIVES To examine association of candidate genetic variants in structural, inflammatory, matrix modifying, vitamin D receptor genes and variants associated with osteoarthritis, with surgical candidates and surgical patients with lumbar disc degeneration (LDD), in light of their previously reported susceptibility for LDD. METHODS Genotyping of 146 Norwegian LDD patients and 188 Norwegian c...

2016
Maxim B. Freidin Toma Keser Ivan Gudelj Jerko Štambuk Dunja Vučenović Massimo Allegri Tamara Pavić Mirna Šimurina Stella M. Fabiane Gordan Lauc Frances M. K. Williams

Low back pain (LBP) is a common debilitating condition which aetiology and pathogenesis are poorly understood. We carried out a first so far analysis of associations between LBP and plasma IgG N-glycome in a sample of 4511 twins from TwinsUK database assessed for LBP, lumbar disc degeneration (LDD) as its possible cause, and IgG-glycan levels. Using weighted correlation network analysis, we est...

Journal: :In vivo 2015
Manuel Oprea Iulian Popa Anca Maria Cimpean Marius Raica Dan V Poenaru

AIM To investigate a possible correlation between the histological and morphometric properties of herniated intervertebral disc, clinical and magnetic resonance imaging (MRI) characteristics of patients with lumbar disc degeneration (LDD). MATERIALS AND METHODS Thirty six patients with LDD were clinically evaluated using Japanese Orthopaedic Association Score (JOAS), visual analogue scale (VA...

2016
Fatih Aydemir Melih Cekinmez Ozgur Kardes Fazilet Kayaselcuk

Ganglion cell tumors (GCT) are divided into two subtypes : gangliocytoma and ganglioglioma. Intramedullary gangliocytomas are extremely rare. A 20-year-old male patient with pain of neck, who also had a previously known neuroendocrine tumor of lung, was operated for mass found in the cervicomedullary junction with a presumptive diagnosis of metastases. Only partial resection could be performed....

Journal: :BMC Pediatrics 2005
Henning Windhagen Fritz Thorey Heinrich Kronewid Thomas Pressel Dieter Herold Christina Stukenborg-Colsman

BACKGROUND For treatment of Graf class IIb dysplastic hips at walking onset a treatment concept with abduction splints allowing patterns as walking and crawling under constant abduction control was investigated. However, as the splint still incapacitates child movements the research question remains whether the physiologically progressing maturation of hips can be significantly altered using su...

2001
Johnny Holmberg Krister Landernäs Lennart Harnefors Mark Vesterbacka

The computational properties of second-order lossless discrete integrator/differentiator (LDI/LDD) allpass filters are studied, where the resource requirements in bit-serial hardware implementations are given particular interest. The properties of the LDI/LDD filters are compared to the corresponding properties of second-order wave digital (WD) filters using three-port series adaptors. Two impl...

2006
Miin-Horng Juang Yi-Ming Chiu

Effects of a lightly-doped-drain (LDD) implantation condition on the device characteristics of poly-Si TFT have been studied. For a LDD implantation dose of 2–4 × 1013 cm−2, no significantly large difference in on-state current and off-state leakage is found. For a LDD implantation energy of 50–100 keV, however, the higher LDD implantation energy results in smaller off-state leakage and more re...

Journal: :Genetics and molecular research : GMR 2011
W P Lin J H Lin X W Chen C Y Wu L Q Zhang Z D Huang J M Lai

We investigated a possible association between interleukin (IL)-10 single nucleotide polymorphisms (SNPs) and susceptibility to and severity of lumbar disc degeneration (LDD) in a Chinese cohort of 320 patients with LDD and 269 gender- and age-matched controls. The degree of disc degeneration was determined by magnetic resonance imaging using Schneiderman's classification. Genetic analysis of I...

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