Hepatitis C virus (HCV) infection is resistant to interferon-alpha (IFN-alpha) in some patients. The mechanism of this resistance is unknown. Interleukin-1 receptor antagonist (IL-1Ra) is induced by IFN-alpha and is a good indicator of IFN activity. In the current study, we compared IL-1Ra levels in rapid virologic responders and flat responders who showed resistance to IFN. Three groups of pat...

Objective(s): The effects of PPAR-γ agonist alone and in combination with carvacrol and Zataria multiflora on inhaled paraquat (PQ) induced-systemic inflammation and oxidative stress were examined. Materials and Methods: Control group exposed to normal saline aerosol, one group exposed to 54 mg/m3 PQ aerosol and four groups exposed to PQ...

Abstract Objective: Interferon-γ (IFN-γ) is a key cytokine regulating the development of atherosclerosis, but little known regarding phenotype and regulation T cells producing IFN-γ in plaques. Methods: To identify characterize IFN-γ-producing we utilized IFN-γ-YFP Nur77-GFP reporter mice crossed onto an atherosclerotic background (Apoe−/−IFN-γ YFP/YFP; Apoe−/−Nur77GFP/wt), adoptive transfer tr...

Abstract Background Accumulating evidence suggests tRNA-derived fragments (tRFs) play important roles in cellular homeostasis. Here we aimed to explore aberrant expression of tRFs CD4 + T cells from patients with systemic lupus erythematosus (SLE) and their potential function the SLE pathogenesis. Methods First, small RNA sequencing was performed on four three healthy controls (HCs). Candidate ...

OBJECTIVE Numerous observations implicate interferon-α (IFNα) in the pathophysiology of systemic lupus erythematosus (SLE); however, the potential impact of endogenous anti-IFNα autoantibodies (AIAAs) on IFN-pathway and disease activity is unclear. The aim of this study was to characterize IFN-pathway activity and the serologic and clinical profiles of AIAA-positive patients with SLE. METHODS...

Abstract Epstein-Barr virus-positive gastric cancer [EBV (+) GC] is a distinct GC subtype with unique genetic and epigenetic aberrations. Here, we examined resected samples publicly available microarray data The Cancer Genome Atlas (TCGA) database to identify the mechanism underlying overexpression of PD-L1 in EBV GC. We found that high levels were caused by focal amplification CD274 . By contr...

background & aim: multiple sclerosis(ms) is the most common inflammatory disease of central nervous system which is caused by an autoimmune process leading to destruction of myelin sheath. in this disease, cd4+ t–lymphocytes, mostly of th1 phenotype, play important roles in destruction of neuronal tissues.  because of the probable etiologic participation of ebv virus in immunopathogenesis of ms...

Interferon-gamma is produced by immune cells before MS exacerbations, and exogenous IFN-gamma treatment causes MS attacks. IFN-beta production, conversely, rises after exacerbations. IFN-beta therapy ameliorates MS, possibly by lowering IFN-gamma secretion and inhibiting responses to IFN-gamma. IFN-gamma effects are regulated by IFN-gamma receptor (IFNGR) expression. IFN-gamma is pro-inflammato...

objective: understanding gene expression variations by using rna transcript analysis methods during hepatic viral protein interactions with the ifn pathway in hepatic cell lines has recently gained importance. one of the most powerful techniques in gene expression quantification is quantitative real-time rt-pcr. reference genes used as normalizer in this method may be affected across various ex...