نتایج جستجو برای: leukemia cells
تعداد نتایج: 1520577 فیلتر نتایج به سال:
Members of the pre-B-cell leukemia transcription factor (PBX) family homeoproteins are mainly known for their involvement in hematopoietic cell differentiation and development leukemia. The four PBX proteins, PBX1, PBX2, PBX3 PBX4, belong to three amino acid loop extension (TALE) superfamily which important transcriptional cofactors several developmental processes involving homeobox (HOX) facto...
Abstract Chimeric antigen receptor (CAR)-T cell therapy is a promising treatment for lymphoblastic leukemia and lymphoma. Despite initial response to CAR-T therapy, about 40% of patients relapse. Modulating metabolism (immunometabolism) being considering as novel approach improve efficacy. We have identified MCJ (DnaJC15) target enhance mitochondrial metabolism. an endogenous negative regulator...
Aim Central nervous system (CNS) metastasis is a major obstacle in the treatment of leukemia, and the underlying mechanisms of leukemia CNS metastasis are not fully understood. The present study is an investigation of the role of the CNS microenvironment in leukemia CNS metastasis. Methods Analog blood-brain barrier (BBB) was set by coculturing human brain microvascular endothelial cells (HBM...
Cyclic adenosine monophosphate response-element binding protein (CREB) is a nuclear protein that regulates expression of genes that control cell proliferation, differentiation, and survival. To analyze CREB expression in leukemia cells, we conducted Western blot analysis of bone marrow cells obtained from patients with acute lymphoblastic leukemia, patients with acute myeloid leukemia, and pati...
The ex vivo sensitivity of pediatric leukemia cells to the proteasome inhibitor bortezomib was compared to 3 next generation proteasome inhibitors: the epoxyketone-based irreversible proteasome inhibitors carfilzomib, its orally bio-available analog ONX 0912, and the immunoproteasome inhibitor ONX 0914. LC50 values were determined by MTT cytotoxicity assays for 29 childhood acute lymphoblastic ...
Freshly isolated human leukemia cells have been shown in the past to display varying in vitro responses to phorbol diesters, depending on their cell type. Specific receptors for the phorbol diesters have been demonstrated on numerous different cells. This study was designed to characterize the receptors for phorbol diesters on leukemia cells freshly isolated from patients with different kinds o...
Leukemia differs substantially with respect to stromal milieu from tumors that progress locally as solid masses, and the physiological importance of immunosurveillance in leukemia remains unclear. However, currently available mouse leukemia models have critical limitations in the context of analyzing immunological regulation of leukemia development. In this study, we transferred mouse MLL/AF9 l...
Background and Objective: The use of low-molecular-weight, nonpeptidic molecules that degrade the interaction between the p53 protein and its negative regulator MDM2 (Murine- double minute colon 2) is a new therapeutic strategy for treatment of various types of cancer. One of these agents is RITA (reactivation of p53 and induction of tumor cell apoptosis) which binds to p53 protein and inhibits...
Role of Toll‑like receptors in natural killer cell function in acute lymphoblastic leukemia (Review)
Natural killer (NK) cells are specialized lymphocytes primarily involved in the response to infection and tumors. NK characterized by presence of specific surface molecules, as well a wide repertoire receptors that impart microenvironment‑dependent effector functions. Among these receptors, Toll‑like (TLRs) can be activated condition either cytotoxic or immunoregulatory phenotype. However, cell...
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