In a postmortem survey of children with leukaemia and lymphoma, the overall incidence of testicular infiltration was 65% and of ovarian infiltration 66%. In acute lymphoblastic leukaemia, testicular infiltration was found in 25 of 39 cases and ovarian infiltration in 6 of 12 cases. The majority of boys with acute lymphoblastic leukaemia and testicular infiltration also had infiltration in other...

An ecological analysis by Alexander et al observed a small but significant excess of leukaemia excluding chronic lymphoid leukaemia in estuarine wards (relative risk=1.12, 95%CI 1.01, 1.25). This analysis was confined to cases diagnosed during 1984–1986. Using regional leukaemia incidence data for 1981– 1994, we performed a clustering study based on postcode districts of address at diagnosis to...

Hairy cell leukaemia is a rare form of lymphoproliferative disease that affects 2% of leukaemia patients and was first described in 1958 as leukaemic reticuloendotheliosis. The typical presentation is pancytopenia, splenomegaly and abnormal lymphoid cells in blood with hairy cytoplasmic projections. The pathological hairy cell resembles in many ways B-lymphocyte as in chronic lymphocytic leukae...

8. Koizumi H, Kumakiri M, Ishizuka M, Ohkawara A, Okabe S. Leukaemia cutis in acute myelomonocytic leukaemia: infiltration of minor traumas and scars. J Dermatol. 1991;18:281--5. 9. Kristensen IB, Moller H, Kjaershov MW, Yderstraede K, Moller MB, Bergmann OJ. Myeloid sarcoma developing in pre-existing pyoderma gangrenoso. Acta Derm Venereol. 2009;89:175--7. 10. Guinovart RM, Carrascosa JM, Ferr...

AIM To examine the effects of echinomycin, a compound that inhibits DNA-binding activity of hypoxia-inducible factor-1 (HIF1), on leukaemia cell growth. MATERIALS AND METHODS Three acute myeloid leukaemia cell lines and three T-lymphoblastic leukaemia cell lines were cultured with echinomycin. Cell growth, mRNA and protein expression levels were examined by WST-1 assay, reverse-transcription ...

BACKGROUND Over 80% of children with acute lymphatic leukaemia (ALL) survive, but many develop long-term effects after the therapy. The aim of the study was to reveal how much Norwegian adults treated for acute lymphatic leukaemia before the age of 16 know about the risk of long-term effects. MATERIAL AND METHOD The participants (n = 139) were recruited from a cross-sectional study (ALLBARN) ...

OBJECTIVES The role of occupational exposures in hairy cell leukaemia was investigated through a multicentre, hospital based, case-control study. This paper analyses the role of exposure to solvents other than benzene in hairy cell leukaemia. METHODS The study included 226 male cases and 425 matched controls, exposure to solvents was evaluated by expert case by case review of the detailed dat...

Secondary acute leukaemia (s-ALL) is a destructive complication in patients who have been previously treated for other cancer. Secondary acute lymphoblastic leukaemia is rarely reported whereas secondary acute myeloid leukaemia is much more common. Chromosomal 11q23 abnormality, frequently detected in therapy-related acute myeloid leukaemia, is the most common cytogenetic alteration in secondar...

OBJECTIVES To investigate the hypothesis that children of men whose jobs involve contact with many people (particularly children) are at an increased risk of leukaemia. METHODS A population based dataset obtained from routinely collected death certificates involving 14,168 cancer deaths occurring before the age of 15 years registered in England and Wales between 1959-63 and 1970-90. Associati...