The leishmaniases are a spectrum of global diseases of poverty associated with immune dysfunction and are the cause of high morbidity. Despite the long history of these diseases, no effective vaccine is available and the currently used drugs are variously compromised by moderate efficacy, complex side effects and the emergence of resistance. It is therefore widely accepted that new therapies ar...

Leishmaniases are infectious diseases caused by protozoa of the genus Leishmania. They are widely distributed worldwide and endemic in 88 countries in four continents. The present study analyzed the reported cases of American Tegumentary Leishmaniasis (ATL) in Paraná State (Brazil) from January 2007 to December 2013. The data were grouped according to Regional Health (RH) districts and macroreg...

Infectious diseases disproportionately affect the health of populations living in lowand middle-income countries. In addition to the most prevalent diseases, malaria, tuberculosis (TB), and HIV, more than 1 billion people worldwide—most of whom live in remote, rural areas, urban slums, or conflict zones—are also vulnerable to a diverse group of diseases termed neglected tropical diseases (NTDs)...

According to the World Health Organization’s reports, leishmaniases in humans are caused by 20 species of protozoa, belonging to the genus Leishmania1. The parasites are transmitted by the bite of a female tiny, 2–3 mm long insect vector, the phlebotomine sandfly1. Leishmaniasis endemic areas in Kenya are—West Pokot, Kitui, Machakos, Meru, Koibatek and Kajiado districts2–6. Kala-azar (Visceral ...

background: cutaneous and visceral leishmaniases are present in fars province in the south of iran. the current study aimed to evaluate the inter- and intragenic diversities of leishmania species isolated from patients with leishmaniasis in fars province, using pcr-based analyses and dna sequencing of  the n-acetylglucosamine-1-phosphate transferase ( nagt ) gene. methods: clinical samples were...

Objective(s): Leishmaniasis is endemic in 88 countries. Amastigote forms of Leishmania are experts at exploiting host cell processes to establish infection. Monoclonal antibodies are key reagents used in the diagnosis of infectious and non-infectious diseases. The aim of this study was to produce monoclonal antibodies against axenic amastigotes of the Leishmania infantum strain in Iran.Material...