Hemangioblastoma is a rare benign tumor; common by found in the central nervous system, about 25% is associated with Von Hippel-Lindau (VHL) disease. Renal hemangioblastoma is extremely rare. The leiomyoma generally occurs in organs with abundant of smooth muscle such as uterus, gastrointestinal tract or subcutaneous soft tissue. It’s unusual to see it in the kidney, while the renal epithelioid...

Leiomyoma is a benign smooth muscle neoplasm. They can occur in any organ, but the most common forms occur in the uterus, small bowel and the esophagus. Leiomyoma of breast is a rare benign non epithelial tumor. Most leiomyomas in the breast are found in the subareolar region. There are few cases being reported in the literature. Here we report a case of 52 years old lady who presented to us wi...

BACKGROUND A recent clinical trial demonstrated that selective progesterone receptor modulator asoprisnil is effective in reducing uterine leiomyoma volume. We investigated the effects of asoprisnil in vitro on the expression of the extracellular matrix (ECM)-remodeling enzymes and collagens in cultured leiomyoma and matching normal myometrial cells. METHODS The expression of extracellular ma...

BACKGROUND Primary intracranial leiomyoma is an extremely rare occurrence of a low-grade mesenchymal tumor characterized by a proliferation of smooth muscle cells. When present, these lesions predominantly occur in immunocompromised patients in the setting of infection or transplant and have not been known to involve the ventricular system of the brain. In this report, we describe a case of pri...

BACKGROUND Pseudoachalasia is a rare disorder whose presentation strongly resembles idiopathic achalasia. CASE PRESENTATION Here, we present a case of a 42-year-old female patient with esophageal leiomyoma who was initially diagnosed with achalasia. On endoscopical investigation, however, it became apparent that she had pseudoachalasia as consequence of a leiomyoma at the esophagogastric junc...

OBJECTIVE We evaluated the role of MRI as a preoperative diagnostic tool for leiomyoma and adenomyosis. METHOD This is a retrospective chart review at a university-based hospital. The study included 1517 women who underwent hysterectomy or myomectomy over a 5-year period, and 153 women with a preoperative pelvic MRI were included. Comparisons were made between the results of the MRI and posto...

background and objectives: uterine smooth muscle tumors are the most common human neoplasm .they are divided clinically as benign and malignant but there is  another group of  lesions which is difficult to place in these two categories ,so-called smooth  muscle tumors of uncertain malignant potential (stump) and differentiation  of these tumors on the basis of h&e staining is impossible . t...

Uterine leiomyomata, or fibroids, are benign tumors of the uterine myometrium that significantly affect up to 30% of reproductive-age women. Despite being the primary cause of hysterectomy in the United States, accounting for up to 200,000 procedures annually, the etiology of leiomyoma remains largely unknown. As a basis for understanding leiomyoma pathogenesis and identifying targets for pharm...

Uterine leiomyoma are common noncancerous tumors of the uterus and are the most frequent reason for recommending a hysterectomy. This study was conducted to investigate the associations between uterine leiomyoma and lifestyles including glucose metabolism, lipid metabolism and obesity. The case-control study was conducted from January 1st 2012 to December 31st 2012 at Yuhuangding Hospital in Ya...

Background and objective Uterine leiomyoma is the most common benign tumor in females of reproductive age. However, its causes have never been fully understood. The our study was to analyze causal association between various factors uterine using Mendelian randomization (MR). Methods Genetic variables associated with risk were obtained from genome-wide studies. Summary-level statistical data fo...