نتایج جستجو برای: lead discovery
تعداد نتایج: 466038 فیلتر نتایج به سال:
Drugs discovery & design is an intense, lengthy and consecutive process that starts with the lead & target discovery followed by lead optimization and pre-clinical in vitro & in vivo studies. This paper throws light on different computational techniques that play a vital role in the drugs discovery & design process. Earlier, computational techniques are use in the field of computer science, ele...
The application of parallel synthesis to lead optimization programs in drug discovery has been an ongoing challenge since the first reports of library synthesis. A number of approaches to the application of parallel array synthesis to lead optimization have been attempted over the years, ranging from widespread deployment by (and support of) individual medicinal chemists to centralization as a ...
Natural products have been a rich source of lead identification for drug discovery and development. Over the last two decades, the impetus for natural product-based lead discovery in pharmaceutical industry has declined, resulting in a productivity and innovation crisis. Most of the focus is now on high-throughput screening of synthetic libraries of compounds against defined biological targets;...
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