The Phase IIIb, double-blind GUIDE study evaluates the impact of early intervention and prolonged treatment intervals with guselkumab (GUS) on disease course in super responder (SRe) patients (pts) moderate–severe psoriasis (PSO). SRes (PASI=0 at Weeks [W] 20+28 GUS 100 mg Q8W [every 8W] treatment) were randomized to continue or extend Q16W, stratified by duration (short [SDD], ≤2 years [y]; lo...

The RING-in-between-RING (RBR) E3s are a curious family of ubiquitin E3-ligases, whose mechanism of action is unusual in several ways. Their activities are auto-inhibited, causing a requirement for activation by protein-protein interactions or posttranslational modifications. They catalyse ubiquitin conjugation by a concerted RING/HECT-like mechanism in which the RING1 domain facilitates E2-dis...

The article presents an optical displacement transducer with tilt self-correction capabilities. As the transducer components it can be mentioned a pixel linear array (PLA) circuit, a reflective surface and two laser diodes. A data acquisition board performs the control and acquisition tasks, which control the laser diode drivers (LDD) and PLA. Acquiring the digital output signal from the PLA th...

In this paper, a novel method to eliminate the steady-state offset that is encountered when dealing with load change occurs in processes is proposed for identified heat exchanger process model. The algorithm proposed is based on the fact that DMC algorithm is equivalent to an IMC structure. Then we can improve conventional DMC using a modified IMC structure to remove the offset. A simulation re...

Wireless Data dissemination is an effective way to disseminate large amount of data to a large mobile user population. Our project, called “DAYS (DAta in Your Space)”, investigates information management issues in wireless space. One of the main objectives of DAYS is to build a system to provide transactional and web services facilities globally. This paper discusses the creation of a location ...

In this paper, a novel method to eliminate the steady-state offset that is encountered when dealing with load change occurs in processes is proposed for identified heat exchanger process model. The algorithm proposed is based on the fact that DMC algorithm is equivalent to an IMC structure. Then we can improve conventional DMC using a modified IMC structure to remove the offset. A simulation re...

In this paper, a novel method to eliminate the steady-state offset that is encountered when dealing with load change occurs in processes is proposed for identified heat exchanger process model. The algorithm proposed is based on the fact that DMC algorithm is equivalent to an IMC structure. Then we can improve conventional DMC using a modified IMC structure to remove the offset. A simulation re...