نتایج جستجو برای: lcl filter

تعداد نتایج: 124053  

Journal: :Journal of leukocyte biology 2005
Kristina T Lu Rebecca L Dryer Charles Song Lori R Covey

Our previous investigation of a patient (pt1) with non-X-linked hyper-immunoglobulin M syndrome revealed a CD40-mediated defect in B cell activation that resulted in low CD23 expression and absence of germ-line transcription and class-switch recombination. These deficiencies were complemented in vitro by a high threshold of sustained signaling through CD40. To further analyze the signaling defe...

Journal: :Infection and immunity 2002
Muna Qadoumi Inge Becker Norbert Donhauser Martin Röllinghoff Christian Bogdan

Cytokine-inducible (or type 2) nitric oxide synthase (iNOS) is indispensable for the resolution of Leishmania major or Leishmania donovani infections in mice. In contrast, little is known about the expression and function of iNOS in human leishmaniasis. Here, we show by immunohistological analysis of skin biopsies from Mexican patients with local (LCL) or diffuse (DCL) cutaneous leishmaniasis t...

Journal: :The Journal of Experimental Medicine 1978
J M Zarling F H Bach

Lymphocytes sensitized in vitro to a pool of X-irradiated allogeneic normal lymphocytes from 20 individuals develop cytotoxic activity for autologous human lymphoblastoid cells (LCL). Whereas pool sensitized T lymphocytes lyse autologous LCL cells, they fail to lyse autologous B-enriched or T-enriched normal target cells nor autologous phytohemagglutinin (PHA) blasts. In contrast to pool sensit...

Journal: :Colloids and surfaces. B, Biointerfaces 2015
Camila Cubayachi Renê Oliveira do Couto Cristiane Masetto de Gaitani Vinícius Pedrazzi Osvaldo de Freitas Renata Fonseca Vianna Lopez

Iontophoresis is a strategy to increase the penetration of drugs through biological membranes; however, its use has been underexplored in mucosa. The aim of this work was to investigate the influence of iontophoresis in the mucosal penetration of prilocaine hydrochloride (PCL) and lidocaine hydrochloride (LCL), which are largely used in dentistry as local anesthetics, when combined in the same ...

Journal: :Blood 1994
P Seth R Kumari M Dikshit R C Srimal

The effect of nitric oxide (NO) on the luminol-dependent chemiluminescence (LCL) response of rat polymorphonuclear leukocytes (PMNLs) was analyzed by using sodium nitroprusside (SNP), a NO donor, and L-arginine (L-arg), a NO precursor. A significant reduction in the LCL intensity was observed in presence of SNP (100 mumol/L) or L-arg (5 or 10 mmol/L) in arachidonic acid (AA) phorbol ester (PMA)...

2011
Seiji Maruo Bo Zhao Eric Johannsen Elliott Kieff James Zou Kenzo Takada

Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA3C) and EBNA3A are each essential for EBV conversion of primary human B lymphocytes into continuously proliferating lymphoblast cell lines (LCLs) and for maintaining LCL growth. We now find that EBNA3C and EBNA3A’s essential roles are to repress p16 and p14. In the absence of EBNA3C or EBNA3A, p16 and p14 expression increased and cell growth ceas...

Journal: :Journal of animal science 1996
M K Nielsen Y L Kirby A C Clutter

Heritabilities for and genetic and environmental correlations between uterine capacity, ovulation rate, and body mass (BM) were estimated in mice. Uterine capacity was defined as the number of fetuses (LUC or RUC for left or right side) in one uterine horn for unilaterally ovariectomized females. Ovulation rate (corpora lutea, LCL or RCL for left or right ovary) was measured on the remaining si...

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