Bruck Syndrome is a connective tissue disease associated with inactivating mutations in lysyl hydroxylase 2 (LH2/PLOD2) or FK506 binding protein 65 (FKBP65/FKBP10). However, the functional relationship between LH2 and FKBP65 remains unclear. Here, we postulated that peptidyl prolyl isomerase (PPIase) activity of FKBP65 positively modulates LH2 enzymatic activity and is critical for the formatio...

AIMS Chronic heart failure is a complex clinical syndrome with impaired myocardial contractility. In failing cardiomyocytes, decreased signalling efficiency between the L-type Ca(2+) channels (LCCs) in the plasma membrane (including transverse tubules, TTs) and the ryanodine receptors (RyRs) in the sarcoplasmic reticulum (SR) underlies the defective excitation-contraction (E-C) coupling. It is ...

The environmental impacts of packaging manifest themselves at all life-cycle stages. From raw material acquisition, to package manufacture, distribution, recycling and landfilling, packaging systems deplete natural resources, consume energy, produce hazardous waste and emit pollutants. Additionally, each of these stages carries a financial cost. Driven by a desire to minimize financial costs an...

This article explores the possibility of applying the rigid flexibility model to a service setting. The rigid flexibility model was originally developed to explain factors that determine flexibility in a manufacturing environment. Collins and Schmenner (1993) introduced the model and recently, Giovani J.C. da Silveira (2005) reexamined it and provided some empirical validations. Adjusting to a ...

Mapping cropland areas is of great interest in diverse fields, from crop monitoring to climate change and food security. Recognizing the value of a reliable and harmonized crop mask that entirely covers the African continent, the objectives of this study were to (i) consolidate the best existing land cover/land use datasets, (ii) adapt the Land Cover Classification System (LCCS) for harmonizati...

Abstract. The study focuses on the determination of chlorophyll content in four prevailing grasses relict arctic-alpine tundra located Krkonoše Mountains National Park, Czech Republic. We compared two methods for leaf (LCC) – spectrophotometric laboratory, and LCC assessed by fluorescence portable meter CCM-300. Relationships were established between LCCs vegetation indices calculated from spec...

Abstract Zone Umide della Capitanata, located in the northeastern part of Apulia Region, is one most extensive coastal wetlands Italian peninsula and largest components Mediterranean wetland system. Despite its high ecological importance, this site has been undergoing a variety pressures intensified recent decades. This study analyzes evaluates changes occurred area between 2010 2020. Land cove...

The main aim of this study was to assess and mapping land cover (LC) / use (LU), using Remote Sensing (RS) Geographical Information System (GIS) techniques in Elnor natural forest reserve, Blue Nile state, Sudan. also attempted update some information the area such as LC contour map by different methods data transformation analysis Normalized Different Vegetation Index (NDVI), interpolation sup...