Background: Behçet’s disease (BD) is a multi-system inflammatory vascular disorder with auto immunity background. It is a genetic disease that may be affected by environmental factors. Behçet’s disease may involve different organs like urogenital, skin, eyes and gastrointestinal system. According to geographic area and genetic predisposition, prevalence of the disease is different. The aim of...

PURPOSE OF REVIEW Fixed drug eruption is a simplified disease model for elucidating the mechanism(s) of how skin inflammation is induced by skin-resident T cells. In this review, we focus on how the presence of intraepidermal CD8+T cells resident in the fixed drug eruption lesions can provide exciting new clues to our understanding of pathomechanisms of inflammatory skin diseases. RECENT FIND...

The influence of age of onset of Parkinson's disease on the severity and the pattern of motor symptoms was investigated by comparing the motor scores with and without levodopa therapy in two groups of patients divided according to age of onset (early less than 50, late greater than 60 years) and matched for disease duration (n = 69 in each group, Study I). The baseline score, that is, the motor...

BACKGROUND Unlike other respiratory infections, tuberculosis diagnoses increase in summer. We performed an ecological analysis of this paradoxical seasonality in a Peruvian shantytown over 4 years. METHODS Tuberculosis symptom-onset and diagnosis dates were recorded for 852 patients. Their tuberculosis-exposed cohabitants were tested for tuberculosis infection with the tuberculin skin test (n...

MDS: myelodysplastic syndrome SS: Sweet syndrome SSKI: saturated solution of potassium iodide S weet syndrome (SS) is classified as a neutrophilic dermatosis based on its chief clinicopathologic findings: sudden onset of painful, tender erythematous skin lesions (papules, plaques, and nodules) and a diffuse infiltrate of mature neutrophils in the dermis. The skin eruptions, which most frequentl...

basal cell carcinoma (bcc) is the most common cancer of the skin. definite diagnosis usually requires histological examination but recently it has been suggested that cytological examination of skin smear can be used as an alternative. to evaluate sensitivity and specificity of cytological examination, a total of 125 skin lesions, clinically suspected to be bcc were studied. cytological samples...

In 38 cases of prosthetic valve endocarditis, 19 were early cases (onset < 60 days after insertion of prosthesis) and 19, late cases (onset> 60 days). Nine late cases had onsets 12 to 53 months after surgery. The sources or predisposing factors in late cases included dental disease or manipulation; genitourinary tract procedures; and skin, urinary, or wound infections. In contrast, most early c...

A 44-year-old female is described who developed persistent upper extremity and orolingual dystonia several weeks after suspected onset of central pontine myelinolysis (CPM), later confirmed by characteristic pontine lesions on MRI. No foci of the extrapontine myelinolysis were evident. This case confirms that dystonia may be a late and persistent sequela of CPM and may occur in the absence of v...